Acute myeloid leukemia presenting as polyserositis and leukemia cutis

Saxena, Amrish; Bodkhe, Sheetal; Kulkarni, Apurva Rajan; Jain, Ajit Prasad

doi:10.4103/2278-0513.182063

Cited by 3 publications

(1 citation statement)

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“…Cytogenetics and molecular genetics are integral parts of bone marrow evaluation. [14][15][16][17][18][19][20] Retrospective studies have established a greater incidence of SIADs in patients with MDS/CMML compared with the general population and, in one study, compared with patients with chronic myeloid leukemia. Patients with autoimmune disease are at higher risk for development of myelodysplastic syndrome and AML; odds ratio of 1.5 increasing to 2.1 for patients who have autoimmune disease for 10 years or longer.…”

Section: Discussionmentioning

confidence: 99%

Chronic Myelomonocytic Leukemia Presenting With Polyserositis and Seropositivity for Rheumatoid Arthritis

Kunnumpurath

Desikan

McClain

2020

Journal of Investigative Medicine High Impact Case Reports

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Chronic myelomonocytic leukemia (CMML) is a rare clonal stem cell disorder associated with clinical and pathologic of myelodysplasia and myeloproliferation. Systemic autoimmune/inflammatory disorders (SAID) and polyserositis have been associated with CMML. These manifestations can be observed concomitantly, shortly before diagnosis or anytime along the course of illness. We report a case of myeloproliferative CMML who presented with polyserositis and positive serology for rheumatoid arthritis. Retrospective studies of myelodysplasia/CMML have reported 15% to 25% incidence of SAID. The most commonly observed disorders include systemic vasculitis, connective tissue diseases, polychondritis, seronegative arthritis, and immune thrombocytopenia. SAID does not confer adverse prognosis in retrospective studies. Polyserositis is less common; this may result from leukemic infiltrate or result from autoimmunity. Treatment of serositis includes steroids and cytoreductive agents. Serositis may confer poor prognosis and hypomethylating therapy may improve the outcome.

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Section: Discussionmentioning

confidence: 99%

Chronic Myelomonocytic Leukemia Presenting With Polyserositis and Seropositivity for Rheumatoid Arthritis

Kunnumpurath

Desikan

McClain

2020

Journal of Investigative Medicine High Impact Case Reports

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Testicular Myeloid Sarcoma: A Systematic Review of the Literature

Sahu

Sherif

Mishra

et al. 2019

Clinical Lymphoma Myeloma and Leukemia

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Pleural and pericardial effusion revealed underlying acute lymphoblastic leukemia: a case report

Ashour

Ibrahim

Haidar³

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in children. It often presents with signs and symptoms related to bone marrow failure, but any organ can be affected. The extramedullary symptoms of leukemia are frequent and various. However, leukemia rarely causes serous effusions, especially as the first manifestation. Case Presentation: This case report presents a 17-year-old male who developed cardiac tamponade and pleural effusion that led to severe dyspnea. Examinations and diagnostic procedures revealed underlying pre-B-cell ALL. Clinical Discussion: Pleuropericardial effusion in leukemia is often the result of chemotherapy, infection, and relapse. It is rarely the first manifestation of the disease, especially B-cell ALL. However, analysis of the aspirated fluid may reveal an underlying one, which will help make an early diagnosis and administer the appropriate treatment. Conclusion: When approaching a patient with serous effusion, hematological malignancies should be considered the leading cause.

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Acute myeloid leukemia presenting as polyserositis and leukemia cutis

Cited by 3 publications

References 0 publications

Chronic Myelomonocytic Leukemia Presenting With Polyserositis and Seropositivity for Rheumatoid Arthritis

Chronic Myelomonocytic Leukemia Presenting With Polyserositis and Seropositivity for Rheumatoid Arthritis

Testicular Myeloid Sarcoma: A Systematic Review of the Literature

Pleural and pericardial effusion revealed underlying acute lymphoblastic leukemia: a case report

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