Acute myeloid leukemia presenting with diabetes insipidus

Abstract

A central diabetes insipidus should be considered as a sign of primary CNS involvement in patients with acute myeloid leukemia even in the case of normal cerebrospinal fluid and magnetic resonance imaging findings.

Acute myeloid leukemia with diabetes insipidus and hypophyseal infiltration

“…It has been reported that the pathogenesis may include leukemic infiltrate in the hypothalamus‐pituitary area, and our case highlights this etiology. Interestingly, peri‐pituitary leukemic infiltrates have been identified at postmortem in AML patients who did not have clinical CDI .…”

“…Interestingly, peri‐pituitary leukemic infiltrates have been identified at postmortem in AML patients who did not have clinical CDI . As previously reported, clinical CDI has also been described in patients without abnormal radiological findings or cerebrospinal fluid abnormalities suggestive of leukemic infiltration . These patients are reported commonly in association with a rare AML with the recurrent cytogenetic abnormality t(3;3)(q21;q26) with approximately half of the cases having monosomy 7 .…”

Central Diabetes Insipidus

“…10 Review of the English literature of pediatric myeloid malignancies and DI yielded 9 cases (Table 1). [11][12][13][14][15][16][17][18][19] Seven of these patients (78%) had DI at diagnosis of AML/MDS. Cytogenetic data were available in 4 patients, of whom 7 and/or inversion of chromosome 3 was most commonly detected.…”