Acute Myocardial Infarction Clinico Epidem10logical Study

Ramadan, Fardous A; Motaweh, Mohamed

doi:10.21608/mjmu.1992.139456

Cited by 1 publication

(1 citation statement)

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“…The nature of the redox units used varies and includes among others ruthenium tris-bipyridyl complexes, N- (10,12-pentacosadiynoic)-acetylferrocene molecules, ferredoxin analogues, nitro-2,1,3-benzoxadiazol-4-yl units and bis(11-ferrocenylundecyl)dimethylammonium bromide (1)(2)(3)(4)(5). Liposomes bearing surface bound units are also well-known and include fluorescent tags (quantum dots, 6-carboxyfluorescein, rhodamine 101, perylene tethers (6)(7)(8)(9)) and carbohydrates units (10). However, few reports are related to the study of liposomes bearing surface bound redox active units.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Metal Complex Modified Phospholipids by Phospholipase D-Catalyzed Transphosphatidylation

Ledo

Mauzeroll

2009

ECS Trans.

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The synthesis of ferrocenyl-functionalized phospholipid was achieved through a biphasic transphosphatidylation reaction catalyzed by phospholipase D. Thus, the 1,2-distearoyl-sn-glycero-3-phosphocholine headgroup was modified with hydroxymethylferrocene. 1,2-distearoyl-sn-glycero-3-phosphocholine was chosen because it bears a choline group required for successful phospholipase D-catalysis. The use of hydroxymethylferrocene, as an electroactive tether, was appropriate since the present transphosphatidylation reaction is specific to primary alcohols. Mass spectrometry and phosphorus nuclear magnetic resonance analysis confirmed the formation of the redox active phospholipid and also revealed downstream instabilities that will need to be resolved prior to use in liposome assemblies.

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