Acute Myocardial Infarction: Contrast-enhanced Multi–Detector Row CT in a Porcine Model

Accurate myocardial viability assessment is essential to optimize revascularization and/or medical treatment in patients with myocardial infarct. To date, cardiac magnetic resonance imaging (MRI) is the widely accepted clinical standard for visualization, characterization and quantification of myocardial viability. Multidetector computed tomography (CT) is reported by numerous authors as an emerging imaging modality for myocardial viability assessment. This review article summarizes cardiac MRI and CT modalities for myocardial viability assessment.

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“…The area of low attenuation within porcine heart shows good correlation with myocardial blood flow reduction and absolute MI size [59].…”

Section: Cardiac Ct For Myocardial Viability-technical Pointsmentioning

confidence: 86%

Novel MRI and CT Approaches for the Characterization of Myocardial Infarct

et al. 2013

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“…In recent years, CCT has enabled the detection of MI with accurate visualization of infarct size by DE techniques in animal model (38,111) and humans (Figures 8,9) (16). DE may be applied in CCT imaging for the detection of acute and chronic MI with a good accuracy (16,36,112).…”

Section: A B and The Assessment Of MI Ischemia And Viability (88)mentioning

confidence: 99%

Infarct characterization using CT

Grutta

Toia

Maffei

et al. 2017

Cardiovasc. Diagn. Ther.

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Myocardial infarction (MI) is a major cause of death and disability worldwide. The incidence is not expected to diminish, despite better prevention, diagnosis and treatment, because of the ageing population in industrialized countries and unhealthy lifestyles in developing countries. Nowadays it is highly requested an imaging tool able to evaluate MI and viability. Technology improvements determined an expansion of clinical indications from coronary plaque evaluation to functional applications (perfusion, ischemia and viability after MI) integrating additional phases and information in the mainstream examination.Cardiac computed tomography (CCT) and cardiac MR (CMR) employ different contrast media, but may characterize MI with overlapping imaging findings due to the similar kinetics and tissue distribution of gadolinium and iodinated contrast media. CCT may detect first-pass perfusion defects, dynamic perfusion after pharmacological stress, and delayed enhancement (DE) of non-viable territories.

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“…In comparison to gated single photon emission computed tomography and CMR, MDCT has high accuracy in detecting myocardial infarction, although it tends to slightly overestimate the area of infarcted myocardium. 2,3 Measurement of myocardial blood flow by computed tomography was first quantified using electron-beam computed tomography by applying the principles of indicatordilution theory. 4,5 MDCT perfusion data are acquired during the early portion of first-pass circulation of iodinated contrast, as iodinated contrast agents are predominantly intravascular during early first-pass circulation and diffuse to the extravascular space over time.…”

Section: Left Ventricle: Evaluation Of Perfusion and Scarmentioning

confidence: 99%

Beyond the Coronary Arteries: Evolving Applications of Multi-detector Cardiac Computed Tomography in the Assessment of Non-coronary Structures

Xu¹,

Seneviratne²,

Nasis³

2016

ICFJ

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<p>Beyond the assessment of coronary artery anatomy, multi-detector computed tomography (MDCT) can be used to provide detailed structural evaluation of multiple non-coronary structures. The purpose of this review is to provide a clinical update on the evolving niche applications of MDCT in the assessment of non-coronary structures, including the assessment of the left ventricle for perfusion and scar, the evaluation of the right ventricle, pericardium and coronary anomalies. Additionally, the roles of MDCT in the assessment of congenital heart disease and intra-cardiac masses will be reviewed.</p>

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Acute Myocardial Infarction: Contrast-enhanced Multi–Detector Row CT in a Porcine Model

Abstract: Multi-detector row CT with retrospective ECG gating permits the detection and further characterization of acute myocardial infarction in a porcine model of complete coronary occlusion.

Cited by 135 publications

References 20 publications

Novel MRI and CT Approaches for the Characterization of Myocardial Infarct

Novel MRI and CT Approaches for the Characterization of Myocardial Infarct

Infarct characterization using CT

Beyond the Coronary Arteries: Evolving Applications of Multi-detector Cardiac Computed Tomography in the Assessment of Non-coronary Structures

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