Acute myocardial infarction immediately after second vaccination for coronavirus disease 2019

Background Reports of intravascular thrombosis and cardiac complications have raised concerns about the safety of COVID‐19 vaccinations, particularly in patients with high cardiovascular risk. Herein, we aimed to analyze the impact of preoperative COVID‐19 vaccination on outcomes after coronary artery bypass grafting (CABG). Methods and Results Among 520 patients who underwent isolated CABG from 2020 to 2022, 481 patients (mean±SD age: 67±11 years, 86 women) whose COVID‐19 vaccination status could be confirmed were included. A total of 249 patients who had not received any COVID‐19 vaccine before CABG (never vaccinated group) and 214 patients who had completed primary vaccination (fully vaccinated group) were subjected to 1:1 propensity score matching, and 156 pairs of patients were matched. There was no significant difference in early mortality between the 2 groups after matching. After matching, overall survival ( P =0.930) and major adverse cardiovascular and cerebrovascular event‐free survival ( P =0.636) did not differ between the 2 groups. One‐year graft patency also did not differ significantly between the 2 groups; all patent grafts in 85/104 patients (82%) and 62/73 patients (85%) in the never vaccinated and fully vaccinated groups, respectively ( P =0.685). Subgroup analysis showed equivalent overall and major adverse cardiovascular and cerebrovascular event‐free survival among AstraZeneca and Pfizer vaccine recipients and between those with ≤30 days versus >30 days from vaccination to CABG. Conclusions Despite the very high cardiovascular risk for patients undergoing CABG, COVID‐19 vaccination did not affect major outcomes after CABG. Therefore, there is no reason for patients with coronary artery disease requiring CABG to avoid preoperative COVID‐19 vaccination.

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Myocardial Infarction Following Vaccination Against COVID-19: A Systematic Review

Rahimi Petrudi,

Abdollahi,

Mirzaii-Dizgah

2023

Ann Mil Health Sci Res

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Context: Several reports have been presented regarding the occurrence of acute myocardial infarction following vaccination against COVID-19. Objectives: The current systemic review tried to review and summarize the published evidence and documents regarding the occurrence of myocardial infarction following various types of anti-COVID-19 vaccines (AstraZeneca and Pfizer) and, finally, take steps to clarify the causes of such incidents. Methods: The relevant databases, including Medline, Web of Knowledge, Google Scholar, Scopus, and Cochrane, were comprehensively searched by the two blinded researchers for all eligible studies based on the considered keywords. Of 76 articles initially collected by database searching, 20 articles were included in the last analysis. Results: The occurrence of acute myocardial infarction was mostly related to SARS-CoV-2-based messenger RNA and viral vector vaccines. This cardiac attack occurred after the first vaccination in 74% of patients affected. The time of occurrence of myocardial infarction was also very different between different types of vaccines and varied between 15 minutes and 21 days after vaccination. Most of the myocardial infarctions that occurred after vaccination were of the ST-segment elevation type (STEMI) (23 of 28 patients). More than two-thirds of myocardial infarction cases occurred in patients who had significant cardiovascular risk profiles (hypertension, diabetes mellitus, and ischemic heart disease). Overall, 22.2% of cases suffering post-vaccination myocardial infarction died within hospitalization. Conclusions: The occurrence of myocardial infarction following the vaccination against COVID-19 is rare, and due to the fatality of this event, it is necessary to modify the biotechnological production of existing vaccines and to accurately evaluate the pathophysiology of this event.

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Acute myocardial infarction immediately after second vaccination for coronavirus disease 2019

Cited by 3 publications

References 12 publications

Tozinameran

Tozinameran

Influence of Preoperative COVID‐19 Vaccination on Outcomes After Coronary Artery Bypass Grafting—A Propensity Score–Matched Analysis

Myocardial Infarction Following Vaccination Against COVID-19: A Systematic Review

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