Acute myocardial infarction in a patient with chronic myelocytic leukemia during chemotherapy with hydroxyurea

Kälsch, Hagen; Wieneke, Heinrich; Erbel, Raimund

doi:10.1007/s00059-010-3367-6

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Unwarranted interactions of treatments such as HU with tissues may potentially limit their usefulness. In this respect, it is interesting to note that acute myocardial infarction was reported during chemotherapy involving HU in patients without prior heart disease, related to coronary artery spasm, endothelial injury as well as coagulation disorders [78].…”

Section: Discussionmentioning

confidence: 99%

Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype

Masoud

McDonald

Bister

et al. 2019

IJMS

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Much effort is focussed on understanding the structural and functional changes in the heart that underlie age-dependent deterioration of cardiac performance. Longitudinal studies, using aged animals, have pinpointed changes occurring to the contractile myocytes within the heart. However, whilst longitudinal studies are important, other experimental approaches are being advanced that can recapitulate the phenotypic changes seen during ageing. This study investigated the induction of an ageing cardiomyocyte phenotypic change by incubation of cells with hydroxyurea for several days ex vivo. Hydroxyurea incubation has been demonstrated to phenocopy age- and senescence-induced changes in neurons, but its utility for ageing studies with cardiac cells has not been examined. Incubation of neonatal rat ventricular myocytes with hydroxyurea for up to 7 days replicated specific aspects of cardiac ageing including reduced systolic calcium responses, increased alternans and a lesser ability of the cells to follow electrical pacing. Additional functional and structural changes were observed within the myocytes that pointed to ageing-like remodelling, including lipofuscin granule accumulation, reduced mitochondrial membrane potential, increased production of reactive oxygen species, and altered ultrastructure, such as mitochondria with disrupted cristae and disorganised myofibres. These data highlight the utility of alternative approaches for exploring cellular ageing whilst avoiding the costs and co-morbid factors that can affect longitudinal studies.

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Section: Discussionmentioning

confidence: 99%

Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype

Masoud

McDonald

Bister

et al. 2019

IJMS

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“…In another case report showing that 5-FU can cause coronary atherosclerotic heart disease, a 59-year-old male patient with CML developed myocardial infarction after 5-FU treatment despite having no prior history of heart disease and no typical risk factors for coronary artery disease ( Table 5 ). Emergency coronary angiography revealed a complete occlusion of the proximal descending branch of the left coronary artery ( 61 ).…”

Section: Chemotherapeutic Drugsmentioning

confidence: 99%

Coronary atherosclerosis and chemotherapy: From bench to bedside

Zhou

Zhu

Liu

et al. 2023

Front. Cardiovasc. Med.

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Cardiovascular disease, particularly coronary artery disease, is the leading cause of death in humans worldwide. Coronary heart disease caused by chemotherapy affects the prognosis and survival of patients with tumors. The most effective chemotherapeutic drugs for cancer include proteasome inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, 5-fluorouracil, and anthracyclines. Animal models and clinical trials have consistently shown that chemotherapy is closely associated with coronary events and can cause serious adverse cardiovascular events. Adverse cardiovascular events after chemotherapy can affect the clinical outcome, treatment, and prognosis of patients with tumors. In recent years, with the development of new chemotherapeutic drugs, new discoveries have been made about the effects of drugs used for chemotherapy on cardiovascular disease and its related mechanisms, such as inflammation. This review article summarizes the effects of chemotherapeutic drugs on coronary artery disease and its related mechanisms to guide efforts in reducing cardiovascular adverse events during tumor chemotherapy, preventing the development of coronary heart disease, and designing new prevention and treatment strategies for cardiotoxicity caused by clinical tumor chemotherapy.

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“…In particular, the combination of cardiotoxic chemotherapeutics with radiation can lead to an excess risk [27,43]. The most important group of anticancer drugs enhancing the risk of cardiovascular damage is anthracyclines such as epirubicin, doxorubicin, and daunorubicin.…”

Section: Non-radiation-related Risk Factors For Cardiovascular Damagementioning

confidence: 99%

Cardiac side effects of conventional and particle radiotherapy in cancer patients

Wittig

Engenhart‐Cabillic

2011

Herz

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Acute myocardial infarction in a patient with chronic myelocytic leukemia during chemotherapy with hydroxyurea

Cited by 5 publications

References 7 publications

Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype

Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype

Coronary atherosclerosis and chemotherapy: From bench to bedside

Cardiac side effects of conventional and particle radiotherapy in cancer patients

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