Acute myocarditis following administration of BNT162b2 vaccine

Abstract

Highlights To highlight acute myocarditis as a potential adverse complication of BNT162b2 vaccine. To illustrate the clinical approach and investigations of myocarditis secondary to BNT162b2 vaccine. Conservative management might be reasonable in mild cases.

A Late Presentation of COVID-19 Vaccine-Induced Myocarditis

“…Myocarditis has been traditionally described as an inflammation of the myocardial wall, which can lead to a variety of structural and conduction abnormalities [1,4]. Post-vaccination myocarditis has been previously described after smallpox and influenza vaccines [1,4,5,7].…”

“…Myocarditis has been traditionally described as an inflammation of the myocardial wall, which can lead to a variety of structural and conduction abnormalities [1,4]. Post-vaccination myocarditis has been previously described after smallpox and influenza vaccines [1,4,5,7]. The BNT162b2 and mRNA-1273 vaccines have been shown to confer a protection rate of 95% and 94.1% against symptomatic COVID-19 in individuals aged 16 or older, respectively [2].…”

“…The coronavirus disease 2019 (COVID-19) pandemic has incurred significant morbidity and mortality across the globe [1]. The cardiovascular manifestations of an acute COVID 19 infection include acute coronary syndrome, as well as myocarditic inflammation [2].…”

“…The cardiovascular manifestations of an acute COVID 19 infection include acute coronary syndrome, as well as myocarditic inflammation [2]. With the development and recent introduction of COVID-19 vaccines, the incidence of severe infection has significantly decreased [1]. While the COVID-19 vaccine has been proven to be effective and safe across various populations, there have been few case reports of acute myocarditis within 3-5 days following the second dose of the COVID-19 vaccine [1,[3][4][5][6][7][8][9].…”

“…With the development and recent introduction of COVID-19 vaccines, the incidence of severe infection has significantly decreased [1]. While the COVID-19 vaccine has been proven to be effective and safe across various populations, there have been few case reports of acute myocarditis within 3-5 days following the second dose of the COVID-19 vaccine [1,[3][4][5][6][7][8][9]. According to the Centers for Disease Control and Prevention (CDC), >1000 reports of vaccine-induced myopericarditis have been recorded by the Vaccine Adverse Event Reporting System [10].…”