Acute Myopericarditis Due to Human Granulocytic Anaplasmosis

Abstract

We present a case of a 54-year-old gentleman with a history of hypertension and chronic HIV who presented with fever and epigastric pain, found to have elevated troponin-I levels and diffuse ST-segement elevations on ECG without clinical evidence of ischemia concerning for myopericarditis. Initial laboratory findings also included thrombocytopenia and elevated aminotransferases as well as computed tomography imaging revealing splenic infarcts. Given plausible exposure to ticks, this led to the eventual diagnosis of anaplasmosis confirmed on PCR assay. Cardiac MRI images confirmed myocardial involvement, which resolved with antibiotic treatment. While rare, cardiac involvement is possible sequelae of anaplasmosis infection as illustrated by this case.

Detection of Anaplasma phagocytophilum in an inflammatory pericardial effusion of a dog

“…phagocytophilum associated myopericarditis in humans. 7 , 8 , 9 The inflammatory pericardial effusion that was present in this dog is suggestive of pericarditis, however, a pericardial biopsy was not pursued to confirm this. A troponin level was not performed so it is unknown if there was myocarditis in this dog.…”

“…phagocytophilum , are reported to cause myocarditis and pericarditis in humans. 7 , 8 , 9 Here, we describe a case of pericardial effusion associated with A . phagocytophilum in an 11‐year‐old female spayed German Wirehaired Pointer dog.…”