Acute nateglinide administration in subjects with type 2 diabetes: effects on postprandial metabolism, coagulation, and fibrinolysis

Effects of mealtime insulin aspart and bedtime neutral protamine Hagedorn insulin on postprandial coagulation and fibrinolysis in patients with type 2 diabetes

“…Also, there were no significant correlations between the glucose response (AUC or postprandial mean) and the response of FVIIa, D-dimer, F1+2, t-PA and PAI. Other studies support our observations showing that mealinduced hyperglycaemia does not cause coagulation activation and reduces concentrations of fibrinolytic variables [24,25]. Changes in F1+2 and fibrinolytic variables most probably reflect diurnal variations [26,27].…”

Pharmacological interventions for preventing or delaying onset of type 2 diabetes mellitus

“…The rationale was based on a combination of epidemiologic evidence showing a correlation between postprandial hyperglycaemia and cardiovascular events [72,73] and preclinical evidence that minimizing the 'postprandial storm' characterized by elevated glucose and triglyceride levels might alter cardiovascular risk. Treatment with nateglinide in small clinical trials was shown to improve endothelial function, reduce oxidative stress, platelet activity and inflammatory markers, and diminish the progression of carotid-IMT [74][75][76][77]. However, in NAVIGATOR, nateglinide did not significantly reduce cardiovascular event rates in the core (cardiovascular death, non-fatal MI, non-fatal stroke and hospitalization for heart failure) or extended (core events and hospitalization for unstable angina or arterial revascularization) cardiovascular composite outcomes (core: HR 0.94, 95%-CI 0.82-1.09; p = 0.43; extended: HR 0.93, 95%-CI 0.83-1.03; p = 0.16).…”

A Unique Case of Basal-Bolus Therapy

“…Antibodies to GAD are predictive of progression to hyperglycemia in the absence of ICAs or IAAs and have been shown to have a positive predictive value of 50% and a negative predictive value of 97% for late insulin deficiency. 3 Moreover, the presence of two or more autoantibodies is highly predictive of the development of type 1 diabetes. 4 Nonetheless, some type 1 diabetic patients remain negative for all antibody types.…”