2006
DOI: 10.1016/j.pediatrneurol.2005.07.007
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Acute Necrotizing Encephalopathy Associated With Human Herpesvirus-6 Infection

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Cited by 45 publications
(36 citation statements)
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“…Other authors describe high plasma concentrations of interleukin 6 and tumor necrosis factor-α, suggesting that proinflammatory cytokines may be mediators of damage 16 . A local breakdown of the blood-brain barrier and an immunogenetic mechanism rather than direct invasion of the virus were suggested in the pathogenesis of acute necrotizing encephalopathy of childhood 7,10,17 . This may explain the lack of CSF pleocytosis and increase in CSF protein.…”
Section: Discussionmentioning
confidence: 99%
“…Other authors describe high plasma concentrations of interleukin 6 and tumor necrosis factor-α, suggesting that proinflammatory cytokines may be mediators of damage 16 . A local breakdown of the blood-brain barrier and an immunogenetic mechanism rather than direct invasion of the virus were suggested in the pathogenesis of acute necrotizing encephalopathy of childhood 7,10,17 . This may explain the lack of CSF pleocytosis and increase in CSF protein.…”
Section: Discussionmentioning
confidence: 99%
“…Su presentación clínica es inespecífi ca pero la combinación de encefalopatía aguda, convulsiones y progresión rápida al coma, más los hallazgos en la TAC de lesiones talámicas bilaterales hacen muy probable el diagnóstico de ENA. Se ha establecido que la ENA se asociada en la mayoría de los casos a infecciones por infl uenza A (H3N2) y B. También han sido descritos otros agentes causales como VHH6, Coxsackie A9 y Mycoplasma pneumoniae 13 . En general, la ENA es una condición esporádica y que no recurre.…”
Section: Discussionunclassified
“…Нередко характер поражения мозга описывается как тяжелый панэнцефалит или очаговый некротический энцефа-лит [40]. С ВГЧ6-инфекцией связывают также разви-тие медиальной височной эпилепсии [41].…”
Section: российский вестник перинатологии и педиатрии 2016; 61:5 Rosunclassified