Acute Necrotizing Encephalopathy of Childhood: Report of a Spanish Case

Millán, Beatriz San; Teijeira, Susana; Penin, Carmen; García, Jorge Mendoza; Navarro, Carmen

doi:10.1016/j.pediatrneurol.2007.07.007

Cited by 29 publications

(46 citation statements)

References 12 publications

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“…Areas of venous and capillary congestion were seen, associated with petechiae. No signs of inflammatory infiltrates or reactive proliferation of the astrocytes or the microglia cells were found 5 20…”

Section: Discussionmentioning

confidence: 99%

“…Acute encephalopathy with thalamotegmental involvement in children is an extremely rare form of acute encephalopathy 5. It is a condition more often reported in countries of eastern Asia such as Japan, Taiwan and South Korea; nevertheless, some cases have been described in Europe and in the Americas 3 6–9…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of cerebrospinal fluid reveals moderate pleocytosis associated with a slight increase in protein levels 4 5 14. EEG presentation is more evident during the acute phase of the disease, with alterations to basic rhythm, generally in the form of generalised, slow non-synchronous waves 14…”

Section: Discussionmentioning

confidence: 99%

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Acute encephalopathy with bilateral thalamotegmental involvement and a benign course: a case report from Brazil

Alvarenga

Neri²,

Mendonça³

et al. 2011

Case Reports

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SummaryThis rare encephalopathy that generally affects children is preceded by a respiratory infection and fever associated with convulsions and may progress to coma. Outcome is catastrophic in most cases. This case report describes a Brazilian child of African descent with fever, cephalea and bilateral amaurosis, who evolved to coma with pyramidal signs and associated convulsions. MRI showed diffuse, symmetrical lesions in the thalamotegmental region and brainstem. Following administration of methylprednisolone, the clinical condition of the patient improved and the brain lesions regressed, leaving the child with no current neurological defi cits. This was a case of acute postinfectious encephalopathy, involving various brain structures. Outcome was favourable with no sequelae following therapy. This case was atypical due to the bilateral visual involvement and extensive encephalic lesions in a child of African descent with no neurological sequelae following therapy. No other similar cases have been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Acute encephalopathy with bilateral thalamotegmental involvement and a benign course: a case report from Brazil

Alvarenga

Neri²,

Mendonça³

et al. 2011

Case Reports

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“…Regarding the outcome in patients, younger than 2 years of age, those with high serum aminotransferase level, high protein levels of cerebrospinal fluid, and those with brain stem lesions are thought to be poor prognostic factors 2,7,12,20 . The normal transaminase and CSF protein levels and lack of brain stem involvement in the neuroimaging findings of the present case were consistent with the good prognostic factors of the disease.…”

Section: Discussionmentioning

confidence: 99%

Çocukluk çağının akut nekrotizan ensefalopatisi: Türkiye'den bir olgu

Ünver¹,

Hasıloğlu²,

Şahin³

et al. 2014

Cukurova Medical Journal

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Acute necrotizing encephalopathy of childhood is a rare form of acute encephalopathy of unknown etiology characterized by typical symmetrical lesions in the thalami, with variable involvement of the white matter, brainstem and cerebellum. Clinically there is a rapid neurologic deterioration after a short period of a nonspecific viral-like illness associated with gastrointestinal or respiratory signs. Asian children are especially affected. Here we present a 3-yearold boy admitted to our hospital with fever and deterioration of consciousness. His nasopharyngeal swab for polymerase chain reaction revealed positive results for human parainfluenza 2 virüs. The diagnosis of acute necrotizing encephalopathy was made by cranial magnetic resonance imaging findings with symmetrical expansile hyperintense signals in bilateral thalami.

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“…Die bei unserer Patientin nachgewiesene basale Kontrastmittelanreicherung der Meningen zählt nicht zu den pathognomischen Veränderung, schließt die Diagnose ANE jedoch nicht aus. Postmortal kann die Diagnose neurohistopathologisch gesichert werden [6].…”

Section: Introductionunclassified