Acute necrotizing encephalopathy with organic psychosis: a pediatric case report

Abstract

Background. Enteroviruses-associated acute necrotizing encephalopathy (ANE) of childhood is rarely reported in the literature. Clinico-radiological features of ANE are well-recognized and bilateral thalamic nuclei are frequently affected by ANE. Neuropsychiatric symptoms are rarely seen. Thalamic damage can cause psychosis. Case. Herein, we present a pediatric case of enterovirus-associated ANE presenting with psychosis related to thalamus damage in whom a favorable response to treatment was achieved. Conclusion. Thalamic damage occurs during the Enteroviruses-associated acute necrotizing encephalopathy and it can be related psychiatric sympthoms. Clinicians should be aware of uncommon presentations of ANE, and patients with thalamic damage should be followed for neuropsychiatric manifestations. Early recognition and appropriate treatment of ANE is important to obtain favorable outcomes.

Recurrent Acute Necrotizing Encephalopathy Associated With Family History of Encephalopathy: Clinical Experience And Literature Review

“…About 30% children may die in acute encephalopathy stage. Among patients who were lucky enough to get through the second period, less than 10% of them recovered completely in the third period [3]. This child admitted to hospital twice for seizures, the rst time his prodromal period was so short that the boundary between prodromal and acute encephalopathy stage was not clear.…”

“…First reported in 1995 acute necrotizing encephalopathy (ANE) often occurs in children, especially in infants aged 6-18 months [1,2]. The main performance is as follows: fever, cough, vomit, convulsion, unconsciousness, rash, disseminated intravascular coagulation and liver dysfunction [3,4,5]. Although the incidence rate is only 1 in 1000,000, its mortality rate is high because of its rapid process [2].…”