Acute Nicotine Differentially Impacts Anticipatory Valence- and Magnitude-Related Striatal Activity

Rose, Emma Jane; Ross, Thomas J.; Salmeron, Betty Jo; Lee, Mary; Shakleya, Diaá M.; Huestis, Marilyn A.; Stein, Elliot A.

doi:10.1016/j.biopsych.2012.06.034

Cited by 53 publications

(74 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only the SFG ROI failed to show the GROUP effect. This widespread reduction in valence processing for smokers is consistent with previous results in an independent cohort (Rose et al, 2013).…”

Section: Valence Cuessupporting

confidence: 92%

“…When considering positively valenced cues, a GROUP × PILL × PATCH interaction was observed bilaterally in the tail of the putamen (Figure 2a). Consistent with previous results (Chaudhri et al, 2006,Rose et al, 2013, both smokers and non-smokers showed enhanced activation in response to nicotine administration while on the placebo pill. Interestingly, nicotine administered to abstinent smokers seemed to normalize activity to levels comparable to that of non-smokers under placebo.…”

Section: Valence Cuessupporting

confidence: 92%

“…Further, when pill ORDER (VAR-first vs placebo-first) was included in the statistical model (that is, ORDER × GROUP × MAGNITUDE × PILL × PATCH) no significant ORDER-related effects or interactions were observed nor were any of the results discussed below altered by the inclusion of ORDER in the model. Consistent with our previous study (Rose et al, 2013), region of interest (ROI) analysis was performed in a priori hypothesized and small volume-corrected (SVC) rewardpathway regions (Supplementary Fig S3). Bilateral ROIs were placed in the striatum (NAcc, caudate, and putamen) and medial prefrontal cortex (Brodmann's area (BA) 10, corresponding to the superior frontal gyrus (SFG) and BA 32, corresponding to the ACC).…”

Section: Discussionmentioning

confidence: 99%

“…Participants completed a revised version of the MID task (MID-R; (Rose et al, 2013)) designed to ascertain the brain circuitry involved in the anticipation and receipt of monetary losses and gains (Knutson et al, 2000(Knutson et al, , 2001. For participants, the task goal was to maximize overall winnings by minimizing losses and maximizing gains.…”

Section: Revised Mid Taskmentioning

confidence: 99%

“…Recent evidence (Rose et al, 2013) using a revised monetary incentive delay (MID) task (Knutson et al, 2000(Knutson et al, , 2001 showed that chronic smoking was associated with reduced valence-dependent activity in the MCL DA reward pathway, whereas acute nicotine administration enhanced striatal activation to stimuli, indicating the magnitude of impending gains (Rose et al, 2013). These findings suggest that the interaction between chronic and acute nicotine exposure has dissociable effects on reward anticipation, which can be localized to the MCL DA reward pathway.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers

Fedota

Salmeron

Ross

et al. 2015

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

Recidivism rates for cigarette smokers following treatment often exceed 80%. Varenicline is the most efficacious pharmacotherapy currently available with cessation rates of 25-35% following a year of treatment. Although the in vivo binding properties are well known, varenicline's neurobiological mechanisms of action are still poorly understood. Varenicline acts as a nicotinic receptor partial agonist or antagonist depending on the presence or absence of nicotine and has been implicated in the reduction of reward signaling more broadly. The current study probed anticipatory reward processing using a revised monetary incentive delay task during fMRI in cohorts of smokers and non-smokers who completed a two-drug, placebo-controlled, double-blind crossover study. All participants underwent~17 days of order-balanced varenicline and placebo pill administration and were scanned under each condition wearing a transdermal nicotine or placebo patch. Consistent with nicotine's ability to enhance the rewarding properties of nondrug stimuli, acute nicotine administration enhanced activation in response to reward-predicting monetary cues in both smokers and non-smokers. In contrast, varenicline reduced gain magnitude processing, but did so only in smokers. These results suggest that varenicline's downregulation of anticipatory reward processing in smokers, in addition to its previously demonstrated reduction in the negative affect associated with withdrawal, independently and additively alter distinct brain circuits. These effects likely contribute to varenicline's efficacy as a pharmacotherapy for smoking cessation.

show abstract

Section: Valence Cuessupporting

confidence: 92%

Section: Valence Cuessupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Revised Mid Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers

Fedota

Salmeron

Ross

et al. 2015

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

Disruption of Reward Processing in Addiction

et al. 2017

View full text Add to dashboard Cite

Striatal hypoactivation in individuals with addiction during reward anticipation and in individuals with gambling addiction during reward outcome is in line with the reward-deficiency theory of addiction. However, the combination of hypoactivation during reward anticipation and hyperactivation during reward outcome in the striatum of individuals with substance addiction may be explained using learning-deficit theory.

show abstract

Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Acute Nicotine Differentially Impacts Anticipatory Valence- and Magnitude-Related Striatal Activity

Cited by 53 publications

References 80 publications

Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers

Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers

Disruption of Reward Processing in Addiction

Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers

Contact Info

Product

Resources

About