Acute nonlymphocytic leukemia in 171 children

Abstract

The initial features, response to therapy, complications, cause of death, and prognostic factors of 171 consecutive children with ANLL are described and compated to historical data for adults with ANLL and for children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL are the absence of a peak age of incidence in ANLL and the far better response to therapy in ALL. Among features present at 100,000/mm3 or above, and no palpable hepatomegaly had significantly longer survivals, while patients with platelet counts below 10,000/mm3 had significantly shorter survivals. The frequency and duration of remission were significantly better with three protocols used since 1968 than previously. However, even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 months, and a median duration of survival of 10 months. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.

Cytochemical and Haematological Studies in Leukemia Patients, Its Appraisal in Classification and Clinical Course of Leukemia

“…97.36% cases of AML showed platelet count <150 thousand.mm3 and in 44.73% cases even below 50 thousand/mm3. These findings are similar documented by Dhal et al [13], Choi et al [14], Weisdrof et al [12].…”

“…Clinical Presentation : Commonest presenting complaints of our patients were weakness (100%) followed by fever (92.1%) > anorexia (89.47%) > bony pain (60.5%) > abdominal pain (50%) > petechial hemorrhages (36.8%) > Epistaxis (21%) which are similar to those described by Choi et al [14]. Presenting signs documented by choi et al (1976) are similar as in our patients like pallor (100%) followed by lymphadenopathy (76.2%) > hepatomegaly (71%) > sterna tenderness (47%).…”

“…Platelet count were below <150 thousand/mm3 in 91.30% cases and 47.8% of cases even below 50 similar findings were documented by Dahi et al . Choi et al, Weisdrof et al [12][13][14].…”

Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000

“…Of the 58 patients treated for AML at St Jude before that time, only one survived for more than 5 years. 1 By 1973, 86 patients with newly diagnosed AML had been treated on three successive St Jude trials. With these simple antimetabolite-based regimens, the rate of complete remission (CR) was 66% and the median duration of remission was 6 months.…”

Testicular Relapse in Acute Myelogenous Leukaemia after 3½ Years of Complete Remission

“…Therefore, an increased number of extramedullary re lapses, mainly in the central nervous system (CNS), have been observed [1][2][3]. Howev er, initial testicular relapses have been rare ly reported [1], In this review we report the case of a boy whose remission was terminat ed by isolated testicular relapse after 3'/2 years. …”