2008
DOI: 10.1089/ham.2007.1043
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Acute Normobaric Hypoxia Stimulates Erythropoietin Release

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Cited by 30 publications
(31 citation statements)
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“…Accordingly, also the alveolar partial pressure of oxygen after respiratory muscle training significantly increased by approximately 10% (Esposito et al 2010). In another article published in this journal by Sanchis-Gomar et al (2009), it was previously shown that intermittent hypoxic treatment is at least as effective as the administration of recombinant human erythropoietin to increase the red blood cell mass and, inherently, the aerobic performances, in agreement with the previous findings of Mackenzie et al (2008). Taken together, these data support the hypothesis that normobaric hypoxia might indeed contribute to improving sports performance.…”
supporting
confidence: 87%
“…Accordingly, also the alveolar partial pressure of oxygen after respiratory muscle training significantly increased by approximately 10% (Esposito et al 2010). In another article published in this journal by Sanchis-Gomar et al (2009), it was previously shown that intermittent hypoxic treatment is at least as effective as the administration of recombinant human erythropoietin to increase the red blood cell mass and, inherently, the aerobic performances, in agreement with the previous findings of Mackenzie et al (2008). Taken together, these data support the hypothesis that normobaric hypoxia might indeed contribute to improving sports performance.…”
supporting
confidence: 87%
“…Eckardt and Kurtz 2005;Jelkmann 2007). This hypoxia-induced EPO production is well established (Erslev 1997;Faura et al 1969;Ge et al 2002;Mackenzie et al 2008). Eckardt et al (1989) have also shown that the EPO response has a dose-dependent nature, since single exposures to simulated altitudes corresponding to 3,000 and 4,000 m above sea level for 5.5 h caused transient increases in EPO levels equivalent to 1.8 and 3.0-fold, respectively.…”
Section: Introductionmentioning
confidence: 64%
“…Increased [EPO] intensifies the red bone marrow progenitor cells activity in red blood-cell production and can subsequently lead to augmented hematocrit and total hemoglobin mass (Levine and Stray-Gundersen 1997;Stray-Gundersen et al 2001). While short periods (90-120 min) of hypoxic exposure have been shown to augment endogenous EPO production (Mackenzie et al 2008;Rodriguez et al 2000), a distinct dose-related response has also been observed. In particular, Eckardt et al (1989) observed a dose-dependent response in EPO release with DPO 2 stimuli of 62 and 80 hPa, resulting from exposures to simulated altitudes, corresponding to 3,000 and 4,000 m, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…85 An increase in EPO levels has been observed after acute exposure to HA. 86 However, after prolonged exposure to hypoxia, EPO does not increase further; on the contrary, its level tends to decrease. 87 In addition, serum EPO levels do not increase further in men with EE at HA.…”
Section: Testosterone and Erythropoiesismentioning
confidence: 97%