“…Two trials provided insufficient information about the volume of blood transfused intra‐ or postoperatively and were not included in most of the analyses 21,22 . Among the 34 trials comparing ANH to usual care, 11 trials were considered large‐volume hemodilution trials 22 .…”
The literature supports only modest benefits from preoperative ANH. The safety of the procedure is unproven. Widespread adoption of ANH cannot be encouraged.
“…Two trials provided insufficient information about the volume of blood transfused intra‐ or postoperatively and were not included in most of the analyses 21,22 . Among the 34 trials comparing ANH to usual care, 11 trials were considered large‐volume hemodilution trials 22 .…”
The literature supports only modest benefits from preoperative ANH. The safety of the procedure is unproven. Widespread adoption of ANH cannot be encouraged.
“…30 Bacher et al found that intramucosal pH was better preserved in normovolemic hemodilution than in controls during cardiac surgery. 31 In hemorrhagic shock, Diebel et al demonstrated a normalization of intramucosal PCO 2 and pH after resuscitation, notwithstanding a hematocrit of 18 Ϯ 2%. 32 Finally, Layland et al showed that intramucosal pH was maintained during normovolemic hemodilution, despite reaching hemoglobin of 8.2 Ϯ 1.4 g/dL.…”
Section: Intramucosal-arterial Pco 2 Gap In Anemic Hypoxiamentioning
DeltaPco2 did not reflect intestinal dysoxia during Vo2/Do2 dependency attributable to hemodilution. Blood flow seems to be the main determinant of DeltaPco2.
“…Of these 1,229 were excluded from further assessment at title and abstract screening, and 36 studies underwent full-text screening (Fig. Twelve studies did not report on our outcomes of interest (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). Excluded Studies.…”
Section: Characteristics Of Included and Excluded Studiesmentioning
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