Acute Oesophageal Necrosis Concurrent with Leishmania chagasi Infection in a Dog

Silva, Juneo Freitas; Guimarães, Luciana; Ribeiro, Lúcia Regina; Moreira, Matheus Vilardo Lóes; Serákides, Rogéria; Ocarino, Natália de Melo

doi:10.1016/j.jcpa.2013.08.003

Cited by 3 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interpretation of clinicopathologic, serologic, and molecular tests should take into account the history (eg, exposure to phlebotomine vectors), signalment (male dogs > 2 years are at high risk), and clinical presentation. The latter is characterized by a wide spectrum of clinical presentations, ranging from infections characterized by the absence of overt clinical findings in the presence of obvious laboratory abnormalities, to more or less marked clinical and laboratory abnormalities that may require hospitalization, especially in cases with severe life‐threatening complications …”

Section: Clinical Signs Of Canine Leishmaniasismentioning

confidence: 99%

“…The latter is characterized by a wide spectrum of clinical presentations, ranging from infections characterized by the absence of overt clinical findings in the presence of obvious laboratory abnormalities, to more or less marked clinical and laboratory abnormalities that may require hospitalization, especially in cases with severe life-threatening complications. [14][15][16][17][18][19][20][21][22][23][24][25][26]…”

Section: Clinical Signs Of Canine Leishmaniasismentioning

confidence: 99%

“…The interpretation of histologic results is well documented by numerous publications describing the typical lesions and the distribution of parasites associated with active disease, mostly characterized by lymphoplasmacytic or granulomatous-pyogranulomatous inflammation and/or by vasculitis either in organs usually affected by Leishmania (bone marrow, spleen, skin, lymph nodes, kidney, etc), and also in unusual tissues such as heart, lung, adrenal gland, genital tract, central nervous system, skeletal muscle, gastrointestinal tract, nails, lacrimal glands, and ocular muscles. [19][20][21]23,26,50,55,56,58,60,61,98,160,[172][173][174][175][176][177][178][179][180][181] Parasite culture and biologic test for infectiousness (xenodiagnosis)…”

Section: Histologymentioning

confidence: 99%

See 2 more Smart Citations

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

149

232

View full text Add to dashboard Cite

Although several reviews on canine leishmaniasis have been published, none thoroughly described clinicopathologic abnormalities and their clinical usefulness. The aim of this review was to provide information concerning current diagnostic tests relevant for clinical pathologists and from a practical perspective. Specifically, in canine leishmaniasis, nonregenerative normocytic normochromic anemia, thrombocytopenia, or leukogram changes may be present. Clinical chemistry and urinalysis may indicate renal dysfunction (azotemia, decreased urine specific gravity, proteinuria) and an inflammatory/immune response (increased acute phase proteins [APP] or α - and/or γ-globulins). Although a potential gammopathy is usually polyclonal, it may also appear oligo- or monoclonal, especially in dogs coinfected by other vector-borne pathogens. When lesions are accessible to fine-needle aspiration (lymphoadenomegaly, nodular lesions, joint swelling), cytology is strongly advised, as the presence of Leishmania amastigotes in a pattern of pyogranulomatous inflammation or lymphoplasmacytic hyperplasia is diagnostic. If the cytologic pattern is inconclusive, the parasite should be identified by histology/immunohistochemistry or PCR on surgical biopsies. Alternatively, cytology and PCR may be performed on bone marrow samples where amastigotes, along with erythroid hypoplasia, myeloid hyperplasia, plasmacytosis, or secondary dysmyelopoiesis can be observed. Dogs with overt leishmaniasis generally have high antibody titers, while low titers predominate in immunologically resistant infected dogs or in exposed dogs with no parasite confirmation. Quantitative serology is recommended in clinically suspect dogs as high-titer antibodies titers may confirm the clinical diagnosis. In confirmed and treated dogs, renal function and inflammatory/immune response variables should be periodically monitored.

show abstract

Section: Clinical Signs Of Canine Leishmaniasismentioning

confidence: 99%