Acute Onset of Auditory Hallucinations After Initiation of Celecoxib Therapy

Lantz, Melinda; Giambanco, Vincent

doi:10.1176/appi.ajp.157.6.1022-a

Cited by 19 publications

(2 citation statements)

References 4 publications

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“…Celecoxib also has been associated with hallucinations. 13 A 78-year-old woman experienced reversible auditory hallucinations 2 days after the start of therapy with celecoxib 200 mg twice/day. Our patient had been taking celecoxib for only 3 months before she reported the adverse effects, which had started nearly a year earlier-well before the start of her celecoxib therapy.…”

Section: Discussionmentioning

confidence: 99%

Alendronate‐Induced Auditory Hallucinations and Visual Disturbances

2004

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A 79-year-old Caucasian woman who had been taking alendronate 10 mg/day for over 2 years to prevent osteoporosis reported hearing "voices in her head" along with red-colored visual disturbances. These auditory hallucinations and visual disturbances began shortly after her regimen was changed from alendronate 10 mg/day to 70 mg once/week. Assessment of causality using the Naranjo and Jones algorithms revealed a "probable" and "highly probable" relationship, respectively, between this adverse drug event and the switch from daily to weekly alendronate therapy. Other bisphosphonates, such as etidronate and pamidronate, have caused both reversible and irreversible auditory, visual, and olfactory hallucinations beginning 2 hours--1 week after drug administration. The mechanism behind these adverse effects is unknown but is thought to be independent of calcium homeostasis. Clinicians should be aware of central nervous system toxicity as a rare but potential adverse effect associated with bisphosphonates.

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Section: Discussionmentioning

confidence: 99%

Alendronate‐Induced Auditory Hallucinations and Visual Disturbances

2004

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“…Speziell hinsichtlich COX−2−Inhibitoren gibt es ± neben so genannten ¹population studies", die keinen detaillierten Auf− schluss erlauben ± auf kasuistisch−detaillierter Basis zwei Fälle über das Auftreten von ¹psychiatric adverse events" [6]. Einer dieser Fälle [7] bezieht sich auf auditorische Halluzinationen un− ter Celecoxib. Der andere Fall [8] beschreibt ein Delir unter Cel− exocib− und Rofecoxibeinnahme.…”

Section: Fallunclassified

Psychotische Störung unter Rofecoxib

Sabolek

Unrath²,

Sperfeld³

et al. 2007

Psychiat Prax

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Acute psychosis is a possible side effect of many centrally acting drugs. Its appearance is facilitated by certain conditions like advanced age, comedication, or comorbidity. We report two cases of acute psychotic syndromes with visual (Case 1 + 2) and auditory (Case 1) hallucinations under rofecoxib, a cyclooxygenase-2-inhibitor. This is one of the first reports of psychotic disorders under rofecoxib intake. We present a review of the literature on mental side effects of NSAID and on the pharmacological basis of the association of cyclooxygenase-inhibitors and mental disorders.

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