Acute Optic Neuropathy in Patients with Behçet’s Disease

Voros, Gerasimos M.; Sandhu, Sukhpal S.; Pandit, Ranjeet

doi:10.1159/000095869

Cited by 22 publications

(26 citation statements)

References 18 publications

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“…A very good response to systemic corticosteroids was noted, similarly to our patient. As reported in a recent review of neurological involvement in BD, early recognition and treatment of optic neuropathy can limit the degree of permanent visual loss, and there is usually a significant response to steroids [5]. Beyond cerebral venous thrombosis and meningocephalitis, the neurological involvement in BD is usually due to parenchymal brain and spinal cord focal lesions.…”

Section: Discussionmentioning

confidence: 97%

Optic neuritis as presenting manifestation of Behçet's Disease with multisystem involvement

Barros¹,

Madureira²,

Pimenta³

et al. 2016

IJCNMH

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Section: Discussionmentioning

confidence: 97%

Optic neuritis as presenting manifestation of Behçet's Disease with multisystem involvement

Barros¹,

Madureira²,

Pimenta³

et al. 2016

IJCNMH

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“…This may be an interesting tool for the misdiagnosed inflammatory ON which may be totally asymptomatic as in our patients 7 and 8 (Table I). Only a handful of such cases have been published original paper (12)(13)(14)(15)(16)(17)(18)(19)(20), with one case with histopathology showing gliosis and demyelination within the nerve (12). Pathological features include disseminated softening foci with mild loss of myelin and glial proliferation, perivascular lymphocyte cuffing and variable wallerian degeneration of white matter tracts (1).…”

Section: N Discussionmentioning

confidence: 99%

Inflammatory optic neuropathy in Behçet’s disease

Khanfir

Belfeki

Saïd³

et al. 2016

Reumatismo

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summary Inflammatory optic neuropathy (ON) is a rare event in Behçet's disease (BD). We report herein a series of ten BD Tunisian patients with ON and describe its clinical features among them. A retrospective review of BD patients (International Study Group for BD criteria) was performed. The patients were divided into two groups: those presenting an inflammatory ON, and those none. The diagnosis of inflammatory ON was based on the clinical examination, visual field and visual evoked potentials. We analyzed the characteristics of the two groups. Ten patients (2.3%) presented an inflammatory ON among our 440 patients. Inflammatory ON was inaugural in 8 cases. Clinical manifestations were as follows: blurred vision (7 cases) and periorbital pain (3 cases). In two cases, the patients did not complain from ophthalmological symptoms. The fundus revealed a papilledema (2 cases), papillary pallor (4 cases), and was normal in 5 cases. Visual field realized in only three patients showed a scotoma in all cases. Visual evoked potentials revealed increased latency in all cases. All patients received corticosteroids associated to an immunosuppressive agent. The comparative study between the two groups revealed that inflammatory ON was significantly more associated to neurological involvement (p<0.0001) and that the disease was more severe in the ON group (p<0.0001). Inflammatory ON in BD is rare and may occur at an early stage of the clinical course of the disease. Its prevalence is certainly underestimated. A systematic visual evoked potential may be interesting as a screening tool.

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“…Cabe destacar el compromiso oftalmológico que tuvo nuestra paciente, con precoz alteración de agudeza visual, de visión de colores y de campo visual, que es sugerente de neuropatía óptica, la cual también se describe como infrecuente en EB, pudiendo ser uni o bilateral y recurrente 12 .…”

Section: Discussionunclassified