Acute Oral Toxicity and Brine Shrimp Lethality of Methanol Extract of &lt;i&gt;Mentha Spicata&lt;/i&gt; L (Lamiaceae)

Naidu, Jegathambigai Rameshwar; Ismail, Rusli; Sasidharan, Sreenivasan

doi:10.4314/tjpr.v13i1.15

Cited by 59 publications

(56 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Syahmi et al have shown that LC 50 values obtained by Brine Shrimp Lethality Assay are in good correlation with LD 50 values obtained by examination of the acute toxicity of E. guineensis methanolic extracts using laboratory Swiss albino mice (Syahmi et al, 2010). Furthermore, using Sprague Dawley rats showed that LD 50 values for the acute toxicity examined by oral route of Mentha spicata methanolic extract are significantly correlated with the LC 50 results obtained by the Brine Shrimp Lethality Assay (Naidu et al, 2014). The LD 50 values for the mice and rats models were above 5000 mg/kg, and the LC 50 values for the brine shrimps were above 1000 µg/ml, indicating that these extracts are non-toxic.…”

Section: Correlation Between Brine Shrimp Assay and Other Animal Modelsmentioning

confidence: 69%

“…Brine Shrimp Lethality Assay is a convenient system for monitoring biological activities of various plant species. Although this method does not provide any adequate information regarding the mechanism of toxic action, it is a very useful method for the assessment of the toxic potential of various plant extracts (Gadir, 2012;Naidu et al, 2014). This method provides preliminary screening data that can be backed up by more specific bioassays once the active compounds have been isolated (Pisutthanan et al, 2004).…”

Section: Advantages Vs Disadvantages Of the Brine Shrimp Assaymentioning

confidence: 99%

“…The toxicity of tested plant samples was determined by comparing their LC 50 values with highly toxic substances suitable to be used as positive controls for this test, such as: vincristine sulphate (Ahmed et al, 2010), potassium dichromate (Naidu et al, 2014), thymol (Sharma et al, 2013;Mirzaei and Mirzaei, 2013), cyclophosphamide (Moshi et al, 2010), pure DMSO (Arlsanyolu and Erdemgil, 2006), caffeine (Gadir, 2012) etc.…”

Section: Preparation Of the Brine Shrimp Assaymentioning

confidence: 99%

“…Due to the ethical issues in toxicological tests, substituting animals with alternative models is very important. The effectiveness of the Artemia salina bioassay for predicting the toxicity of plant extracts was evaluated by comparing the LC 50 results for the brine shrimps with the LD 50 results for acute toxicity in rats and mice (Sharma et al, 2013;Naidu et al, 2014;Parra et al, 2001).…”

Section: Correlation Between Brine Shrimp Assay and Other Animal Modelsmentioning

confidence: 99%

See 3 more Smart Citations

Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model

Hamidi¹,

Jovanova²,

Panovska³

2014

Maced. Pharm. Bull.

211

149

View full text Add to dashboard Cite

Many natural products could serve as the starting point in the development of modern medicines because of their numerous biological and pharmacological activities. However, some of them are known to carry toxicological properties as well. In order to achieve a safe treatment with plant products, numerous research studies have recently been focused on both pharmacology and toxicity of medicinal plants. Moreover, these studies employed efforts for alternative biological assays. Brine Shrimp Lethality Assay is the most convenient system for monitoring biological activities of various plant species. This method is very useful for preliminary assessment of toxicity of the plant extracts. Rapidness, simplicity and low requirements are several advantages of this assay. However, several conditions need to be completed, especially in the means of standardized experimental conditions (temperature, pH of the medium, salinity, aeration and light). The toxicity of herbal extracts using this assay has been determined in a concentration range of 10, 100 and 1000 µg/ml of the examined herbal extract. Most toxicity studies which use the Brine Shrimp Lethality Assay determine the toxicity after 24 hours of exposure to the tested sample. The median lethal concentration (LC 50 ) of the test samples is obtained by a plot of percentage of the dead shrimps against the logarithm of the sample concentration. LC 50 values are estimated using a probit regression analysis and compared with either Meyer's or Clarkson's toxicity criteria. Furthermore, the positive correlation between Meyer's toxicity scale for Artemia salina and Gosselin, Smith and Hodge's toxicity scale for higher animal models confirmed that the Brine Shrimp Lethality Assay is an excellent predictive tool for the toxic potential of plant extracts in humans.

show abstract

Section: Correlation Between Brine Shrimp Assay and Other Animal Modelsmentioning

confidence: 69%

Section: Advantages Vs Disadvantages Of the Brine Shrimp Assaymentioning

confidence: 99%

Section: Preparation Of the Brine Shrimp Assaymentioning

confidence: 99%

Section: Correlation Between Brine Shrimp Assay and Other Animal Modelsmentioning

confidence: 99%

See 2 more Smart Citations

Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model

Hamidi¹,

Jovanova²,

Panovska³

2014

Maced. Pharm. Bull.

211

149

View full text Add to dashboard Cite

show abstract

“…They obtained the equations of motion for the massive particles by using variational principle. Afterwards, many people used this theory to discuss cosmological reconstruction, thermodynamics, viscous solutions, stability of homogeneous universe, dynamical instability, [27,28] etc. The f (R, T, Q) gravity involves usual Lagrangian demonstrating non-minimal association between geometry and matter, where Q = R λσ T λσ .…”

mentioning

confidence: 99%

Stability analysis of stellar radiating filaments

Yousaf

Bhatti

Farwa

2017

Class. Quantum Grav.

View full text Add to dashboard Cite

The aim of this paper is to perform stability analysis of anisotropic dissipative cylindrical collapsing model in f (R, T, R µν T µν ) gravity. In this context, the modified version of hydrodynamical equation is explored by means of dynamical equations and radial perturbation scheme. We examined the role of adiabatic index, dissipation as well as the particular cosmological model on the onset of dynamical instability of the evolving cylindrical system that was initially in hydrostatic equilibrium with Newtonian and post Newtonian approximations. It is pointed out that extra curvature terms of f (R, T, R µν T µµν ) gravity tends to increase the stability, while that heat radiations push the system to enter into unstable window. Further, our results reveal the significance of adiabatic index in the stability analysis of cylindrical celestial model.

show abstract

Microinjection and Oviduct Transfer Procedures for Rat Model Generation with CRISPR-Cas9 Technology

Alcantar¹,

Rairdan²

2018

Methods in Molecular Biology

View full text Add to dashboard Cite

Acute Oral Toxicity and Brine Shrimp Lethality of Methanol Extract of <i>Mentha Spicata</i> L (Lamiaceae)

Cited by 59 publications

References 16 publications

Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model

Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model

Stability analysis of stellar radiating filaments

Microinjection and Oviduct Transfer Procedures for Rat Model Generation with CRISPR-Cas9 Technology

Contact Info

Product

Resources

About