Acute Oral Toxicity ofSalicornia herbaceaL. Extract in Mice

Abstract

is an annual herbaceous plant of Chenopodiaceae. It grows in groups on the coast or mud flat of Korea is known to be rich in minerals. S. herbacea has potent anti-cancer, antioxidant, anti-obesity, bowel function improvement. However, pharmacological mechanisms of S. herbacea extract (SHE) remain poorly understood. The aim of this study was to investigate the potential acute toxicity of SHE in ICR mice administered a single oral dose of 0, 500, 1,000, and 2,000 mg/kg by gavage. After administration of the extract, signs of toxicity were observed every day for 14 days. No mortality, abnormal clinical signs, body weight, organ weight or pathological changes were observed compared to a control group, and there were no differences in the body weights of the control and treatment groups. Biological serum activities and histological tests were not significantly changed in the treatment group compared to the control group. Especially, treatment of SHE was significantly decreased of total cholesterol and triglyceride levels. These results indicated that a single oral administration of SHE does not exerts any toxic effects at a dose of 2,000 mg/kg and that the LD 50 of SHE is greater than 2,000 mg/kg. Accordingly, SHE appears to have potential in various functional agents of foods, without toxicity.

Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury

“…Contrary to our results, extracts of Salicornia herbacea seeds have been reported to have antioxidant activity and cytotoxicity against carcinoma cells in vitro [13]. In addition, there were no reports of renal or liver toxicity using Salicornia herbacea extract [19] or a Chenopodium quinoa (Chenopodiaceae) seed extract [18] at dosages of 2000 mg/kg. Therefore, we hypothesized that SRS may contain toxic substances, since no purification methods were used.…”

“…The limit test dose of 2000 mg/kg b.w. for SRS was used, based on the OECD-423 guidelines [17] and previous studies [18,19]. The selected dosage of CCl 4 was made according to the study of Irie and colleagues [20] as sufficient to cause acute and non-lethal liver injury.…”

A Review on Polyphenols in Salicornia ramosissima with Special Emphasis on Their Beneficial Effects on Brain Ischemia

“…However, this study investigated S. ramosissima as a skin cream application and further clinical studies are needed on the oral safety and tolerability of S. ramosissima polyphenol-rich extracts in humans. In this sense, preclinical studies support both the safety [ 142 ] and the use of S. ramosissima polyphenolic profile for the treatment of ischemia [ 13 , 143 ]. Moreover, Salicornia extracts from other Salicornia species have been better studied in neuroprotection, such as S. europaea [ 144 ] or S. herbacea [ 145 ].…”