Acute orofacial pain

Sharav, Yair; Benoliel, Rafael

doi:10.1016/b978-0-7234-3412-2.10005-7

Cited by 36 publications

(58 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was due to the limited distribution of the discriminative touch receptors (proprioceptors) in the pulp. 7,19,25 Therefore, even though endodontic treatment is considered as a potent dental pain treatment and treatment of choice for irreversible pulpal pathosis, pain may still persist and become idiopathic dental pain or NTP in several cases. 6 Endodontic treatment itself may cause idiopathic dental pain (that may misinterpreted as "fl are ups") at least by several reasons: nerve extirpation cause peripheral axonal injury; 6 patients has to open their mouth for a long time that may cause muscle spasm.…”

Section: Discussionmentioning

confidence: 99%

“…Cortisol, which is normally anti-inflammatory, can change function under severe stress and potentiate the actions of IL-1 and IL-6. 15,19 Kiecolt-Glaser et al, 16 noted that prior trauma "primes" the inflammatory response system so that there is heightened and more rapid rise in inflammation in response to stress. One key to improving the health of trauma survivors is downregulating this stress response and increasing resilience to stress.…”

Section: Down-regulate the Inflammatory Response With Stress Relievinmentioning

confidence: 99%

“…female sexual hormones) 23 may also modulate pain perception. 19,20,22 The intensity of pain from physical injury relates to the attention given, if it is fully absorbed to other subject during the injury (distraction), no pain at all may be felt. Moreover, recent concept of pain is changing; pain management should include body, mind and person.…”

Section: Modulators Of Pain Perceptionmentioning

confidence: 99%

“…music listening), consuming omega-3. 16,17,19 Omega-3 (from fish) in reduced inflammation by competing with AA which is a long chain omega-6 (from meat, egg and dairy products). Excess AA has been associated with increased inflammation because it is converted into PGs and reduced the anti-inflammatory effects of omega-3.…”

Section: Down-regulate the Inflammatory Response With Stress Relievinmentioning

confidence: 99%

“…2 The involvement of trigeminocervical complex makes the pain source detection more difficult. [19][20][21] Another factor complicating diagnosis and management is the very complexity and multidimensionality of pain, with its basis in biological processes but its impact on the emotional, psychological and social wellbeing of the patient (Figure 1). 22 The orofacial region has biological, emotional Figure 1.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Relieving idiopathic dental pain without drugs

Utomo

Rulianto

2011

Dent. J. (Majalah Kedokteran Gigi)

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Down-regulate the Inflammatory Response With Stress Relievinmentioning

confidence: 99%

Section: Modulators Of Pain Perceptionmentioning

confidence: 99%

Section: Down-regulate the Inflammatory Response With Stress Relievinmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Relieving idiopathic dental pain without drugs

Utomo

Rulianto

2011

Dent. J. (Majalah Kedokteran Gigi)

View full text Add to dashboard Cite

(−)-α-Bisabolol reduces orofacial nociceptive behavior in rodents

Melo

Duailibe

Pessoa

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

The purposes of this study were to evaluate the anti-nociceptive effect of oral and topical administration of (-)-α-bisabolol (BISA) in rodent models of formalin- or cinnamaldehyde-induced orofacial pain and to explore the inhibitory mechanisms involved. Orofacial pain was induced by injecting 1.5% formalin into the upper lip of mice (20 μL) or into the temporomandibular joint (TMJ) of rats (50 μL). In another experiment, orofacial pain was induced with cinnamaldehyde (13.2 μg/lip). Nociceptive behavior was proxied by time (s) spent rubbing the injected area and by the incidence of head flinching. BISA (100, 200, or 400 mg/kg p.o. or 50, 100, or 200 mg/mL topical) or vehicle was administered 60 min before pain induction. The two formulations (lotion and syrup) were compared with regard to efficacy. The effect of BISA remained after incorporation into the formulations, and nociceptive behavior decreased significantly in all tests. The high binding affinity observed for BISA and TRPA1 in the molecular docking study was supported by in vivo experiments in which HC-030031 (a TRPA1 receptor antagonist) attenuated pain in a manner qualitatively and quantitatively similar to that of BISA. Blockers of opioid receptors, NO synthesis, and K ATP channels did not affect orofacial pain, nor inhibit the effect of BISA. In conclusion, BISA had a significant anti-nociceptive effect on orofacial pain. The effect may in part be due to TRPA1 antagonism. The fact that the effect of BISA remained after incorporation into oral and topical formulations suggests that the compound may be a useful adjuvant in the treatment of orofacial pain.

show abstract

Chronic Orofacial Pain

Benoliel

Sharav

2010

Curr Pain Headache Rep

Self Cite

View full text Add to dashboard Cite

Chronic orofacial pain (COFP) is an umbrella term used to describe painful regional syndromes with a chronic, unremitting pattern. This is a convenience term, similar to chronic daily headaches, but is of clinically questionable significance: syndromes that make up COFP require individually tailored diagnostic approaches and treatment. Herein we describe the three main categories of COFP: musculoskeletal, neurovascular, and neuropathic. For many years, COFP and headache have been looked upon as discrete entities. However, we propose the concept that because COFP and headaches share underlying pathophysiological mechanisms, clinical characteristics, and neurovascular anatomy, they should be classified together.

show abstract

Acute orofacial pain

Cited by 36 publications

References 97 publications

Relieving idiopathic dental pain without drugs

Relieving idiopathic dental pain without drugs

(−)-α-Bisabolol reduces orofacial nociceptive behavior in rodents

Chronic Orofacial Pain

Contact Info

Product

Resources

About