Acute pain management in burn patients: Appraisal and thematic analysis of four clinical guidelines

Gamst‐Jensen, Hejdi; Vedel, Pernille; Lindberg‐Larsen, Viktoria; Egerod, Ingrid

doi:10.1016/j.burns.2014.08.020

Cited by 54 publications

(35 citation statements)

References 19 publications

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“…Multiple [29] and surface burns [10] tend to be more painful, whereas the region of head/ face/neck, when affected, cause less pain [29]. In this study, most of the subjects were considered averagely burned, had second-degree burn and the lower limbs and trunk were the body segments most affected.…”

Section: Discussionmentioning

confidence: 75%

“…Mismanagement of pain decreases treatment adherence and trust in the health team, in addition to increasing the perception of pain, incidence of chronic pain [2][3][4]10], depression and suicide ideas [3,11].…”

Section: Introductionmentioning

confidence: 99%

“…It is noteworthy that the isolated drug therapy is inadequate to control pain in this type of trauma [7]. Therefore, no pharmacological therapies are recommended in American and European guidelines [10], since they act in different ways in the body. [9,12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is Music Effective For Pain Relief In Burn Victims?

Lima¹,

Correia²,

Nascimento³

et al. 2017

int arch med

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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Is Music Effective For Pain Relief In Burn Victims?

Lima¹,

Correia²,

Nascimento³

et al. 2017

int arch med

View full text Add to dashboard Cite

show abstract

“…Moreover, other burn treatments, such as morphine or gabapentin, are used because they present analgesic properties but lack of anti-inflammatory effects (Gamst-Jensen et al, 2014;McIntyre et al, 2016;Richardson and Mustard, 2009;Singer and Dagum, 2008). The HC-030031 antiedematogenic effect was previously reported through oral or intraplantar administration (Trevisan et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…After thermal lesion, neutrophils and macrophages infiltration to the lesion site is involved not only in the initiation and resolution steps of the acute inflammation but also chronic inflammation (Evers et al, 2010;Fullerton and Gilroy, 2016;Gamst-Jensen et al, 2014;Laycock et al, 2013;McIntyre et al, 2016;de Oliveira et al, 2016). However, an excessive inflammatory cell infiltration may contribute to the sensitization of nociceptors due to the continuous inflammatory mediator's production and release (Laycock et al, 2013;McIntyre et al, 2016;Summer et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Antoniazzi

Prá

Ferro

et al. 2018

European Journal of Pharmaceutical Sciences

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Thermal injury promotes tissue inflammation and pain, which is difficult to control. Different peripheral mechanisms seem to be involved in burn pain, such as free radical-induced damage, but further study is still needed to understand how oxidant substances induced nociceptor sensitization. The transient receptor potential ankyrin 1 (TRPA1) is an ion channel activated by oxidants substances, and it could be sensitized after tissue inflammation. This study evaluated the TRPA1 involvement in nociception and inflammation produced by a thermal injury model. Male Wistar rats were used. The concentration of the TRPA1 antagonist (HC-030031, 0.05%) on base cream was chosen using allyl isothiocyanate intraplantar test. Then, the base cream containing HC-030031 was tested on the thermal injury model (induced by warm water immersion of hind paw, under anesthesia), and silver sulfadiazine (1%) was used as a positive control. Cream treatments on the hind paw were done daily (200 mg/paw) for 6 days after thermal injury. Also, nociception (static and dynamic mechanical allodynia, heat allodynia, and spontaneous pain) or edema were evaluated. On day 6, inflammatory and oxidative parameters were assessed. The base cream containing HC-030031 produced antinociceptive and anti-inflammatory effects (reduced the edema and inflammatory cells infiltration) and decreased the levels of hydrogen peroxide, or superoxide dismutase and NADPH oxidase activities after thermal injury. Thus, this study showed the involvement of the TRPA1 receptor in the nociception and inflammation caused by thermal injury and suggested that TRPA1 antagonists might be useful as novel treatments for pain and inflammation by topical application.

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Efficacy of Smartphone Active and Passive Virtual Reality Distraction vs Standard Care on Burn Pain Among Pediatric Patients

et al. 2021

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IMPORTANCE It is unknown whether smartphone-based virtual reality (VR) games are effective in reducing pain among pediatric patients in real-world burn clinics. OBJECTIVE To evaluate the efficacy of a smartphone VR game on dressing pain among pediatric patients with burns. DESIGN, SETTING, AND PARTICIPANTS This randomized clinical trial included children aged 6 to 17 years who seen in the outpatient clinic of a large American Burn Association-verified pediatric burn center and level I pediatric trauma center between

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Acute pain management in burn patients: Appraisal and thematic analysis of four clinical guidelines

Cited by 54 publications

References 19 publications

Is Music Effective For Pain Relief In Burn Victims?

Is Music Effective For Pain Relief In Burn Victims?

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Efficacy of Smartphone Active and Passive Virtual Reality Distraction vs Standard Care on Burn Pain Among Pediatric Patients

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