Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice

Li, Jun; Xu, Jie; Qin, Xinghua; Yang, Hongyan; Han, Juntao; Jia, Yong; Zhu, Haijing; Zhu, Liang; Li, Jia; Xie, Wenjun; Hu, Dahai; Zhang, Xing; Gao, Feng

doi:10.1016/j.bbadis.2018.11.005

Cited by 18 publications

(13 citation statements)

References 36 publications

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“…Human study was approved by the institutional review board of Fourth Military Medical University and registered at www.chictr.org.cn (ChiCTR-OOB-15006420) as described previously [1] . Once admitted, the Abbreviated Burn Severity Index (ASBI) was calculated [2] and blood samples were randomly collected.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…Patients admitted to the same department receiving skin plastic operation were enrolled as the control. Blood variables were detected and multiple linear regressions were conducted as described previously [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…A total of 1643 blood samples were collected, of which 1358 blood samples were from burn patients and 285 blood samples were from control patients [1] . Linear regressions for blood glucose with serum insulin, glucagon and glucocorticoid as covariates in control and burn patients were conducted ( Fig.…”

Section: Datamentioning

confidence: 99%

“…An expression profile of IL-1 receptor, serum IL-1β and pancreatic islet function were detected in both control mice and burned mice. The data in this article is associated with the research article published in Biochim Biophys Acta “Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: evidence from humans and mice” [1] .…”

mentioning

confidence: 99%

“… Related research article J. Li, J. Xu, X. Qin, H. Yang, J. Han, Y. Jia, H. Zhu, L. Zhu, J. Li, W. Xie, D. Hu, X. Zhang, F. Gao, Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: evidence from humans and mice, Biochim Biophys Acta, (2018). In press [1] . …”

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confidence: 99%

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Dataset on acute hyperglycemia in extensively burned patients and mice

Zhang

2018

Data in Brief

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A single center, prospective cohort study recruiting 107 burn patients and 62 control patients was conducted to characterize the early phase of acute hyperglycemia in patients with burns. A total of 1643 blood samples were collected, and blood glucose and serum proinflammatory cytokines were detected and analyzed. A mouse severe burn model was used to study the underlying mechanisms of acute hyperglycemia postburn. An expression profile of IL-1 receptor, serum IL-1β and pancreatic islet function were detected in both control mice and burned mice. The data in this article is associated with the research article published in Biochim Biophys Acta “Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: evidence from humans and mice” [1].

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Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Section: Datamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Dataset on acute hyperglycemia in extensively burned patients and mice

Zhang

2018

Data in Brief

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High‐resolution magic angle spinning nuclear magnetic resonance of donor pancreatic tissue may predict islet viability prior to isolation

Slupsky,

Sykes,

Lakey

2024

NMR in Biomedicine

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For patients with type 1 diabetes mellitus complicated by severe hypoglycemia, clinical islet transplantation is an efficacious alternative to whole pancreas transplantation. While islet transplantation has improved over the last few years, there remain questions regarding its cost‐effectiveness and donor allosensitization, which is exacerbated when islets from more than one donor are required. Understanding the features of a pancreas that would provide viable islets prior to isolation may lead to development of an accurate assay that could identify suitable pancreases and provide significant cost savings to a clinical islet transplantation program. In this pilot study, solid‐state high‐resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to assess samples of convenience of human pancreatic tissue taken prior to islet isolation both before and after incubation using the two‐layer perfluorocarbon (PFC)/University of Wisconsin (UW) solution cold‐storage method. We observed that, prior to incubation, human pancreatic tissue exhibited evidence of hypoxia with decreased peak integrals associated with glucose and increased peak integrals corresponding to lactate and free fatty acids. After incubation, we observed a reversal of the hypoxia‐induced damage, as integrals corresponding to glucose increased, and those corresponding to lactate and free fatty acid resonances decreased. Interestingly, a significant correlation between the ratio of the glucose integral (at 3.0–4.5 ppm) to the sum of the fatty acid (at 0.9 ppm) and lactate + fatty acid (at 1.3 ppm) integrals and glucose responsiveness, a measure of islet viability, of the isolated islets, was observed after incubation in PFC/UW solution for pancreases that responded to PFC/UW solution incubation (p = 0.02). Notably, pancreases with little or no change in the integral ratio after PFC/UW solution incubation had poor recovery. These results suggest that tissue recovery is a key feature for determining islet cell viability, and further that HRMAS NMR may be a practical method to quickly assess human donor pancreatic tissue prior to islet isolation for clinical transplantation.

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