Acute Pancreatitis: a late complication of dengue fever

Krithika, A P; Ramya, R

doi:10.18203/2349-3291.ijcp20180581

Cited by 4 publications

(1 citation statement)

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“…The correlation between severe dengue and the development of acute pancreatitis have been demonstrated [ 8 , 9 ]. The largest related series between pancreatitis and dengue infection was during an outbreak that occurred in 2002 in Taiwan, in which three patients were diagnosed with dengue hemorrhagic fever and acute pancreatitis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis

Alves

Oliveira²,

Salomão³

et al. 2022

PLoS ONE

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Dengue viral (DENV) infections can lead to acute pancreatitis and associated tissue damage. This study examined the pancreas from two fatal cases of DENV for histopathological changes as well as for the detection of cytokines, and other inflammatory mediators. Tissue sections were prepared for examination by ultrastructural and histopathological techniques. Sections from the pancreas of non-infected individuals were prepared in parallel as a control. The presence of viral replication in macrophages was detected by co-staining for the proteins NS3 and CD68 by immunofluorescence. Immunohistochemistry was used to detect cells that expressed cytokines and inflammatory mediators to characterize the inflammatory response. Edema, acinar necrosis and fibrosis areas associated with a mononuclear infiltrate were found in infected tissues. The major site of virus replication appeared to be macrophages based on their exclusive presentation of the viral protein NS3. Pancreatic tissues from the infected individuals also displayed increased levels of high mobility group box-1, caspase-3, gelatinase B and tumor necrosis factor alpha compared to controls. The presence of virus replicating macrophages in the pancreas was associated with multiple changes in tissue structure that included elevated levels of cytokines and inflammatory markers that may differentiate acute pancreatitis due to DENV infections from other causes.

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Section: Introductionmentioning

confidence: 99%