Acute pancreatitis, ascites, and acute renal failure in Plasmodium vivax malaria infection, a rare complication

Lakhotia, Manoj; Pahadiya, Hans Raj; Kumar, Harish; Jagdish, S; Sangappa, Jainapur Ravi; Choudhary, Piyush

doi:10.4103/2229-5070.162525

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Acute renal failure refers to continually declining glomerular filtration rate followed by the accumulation of nitrogen waste in the body, which leads to metabolic acidosis, hyperkalemia and acute uremic syndrome. Acute renal failure is one of the main causes of death in patients with pancreatitis ( 4 ).…”

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confidence: 99%

Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure

Liu

Cao

Wang

et al. 2017

Experimental and Therapeutic Medicine

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The aim of the study was to investigate the effects of high-volume continuous renal replacement therapy (HV-CRRT) on procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-8 and IL-10 in acute pancreatitis complicated by acute renal failure. Eighty-six patients with acute pancreatitis complicated with acute renal failure were selected from September 2014 to September 2016 in our hospital, and were treated by continuous veno-venous hemofiltration (CVVH). The patients were randomly divided into the observation group, treated by the HV-CVVH model with a displacement rate of 4 l/h, and the control group, treated by the normal capacity model with a displacement rate of 2 l/h. The levels of PCT, TNF-α, IL-4, IL-6, IL-8, and IL-10 in serum were measured by ELISA before and 2, 6 and 12 h after treatment, and 12 h after CVVH. The serum PCT and TNF-α levels in the two groups were decreased at 2 h after treatment. The lowest levels appeared at 6 h after treatment, and then recovered, but remained lower than those before treatment (p<0.05). The levels of IL-4, IL-6, IL-8 and IL-10, as well as PCT and TNF-α in the two groups were significantly lower than those before treatment, and the decreases in the observation group were more obvious than those in the control group (p<0.05). In conclusion, compared with the standard volume method, HV-CRRT can more effectively remove various inflammatory factors and reduce the levels of serum PCT for the treatment of pancreatitis complicated by acute renal failure. Additionally, replacement of the blood filter at appropriate time-points can improve the treatment efficacy.

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Section: Introductionmentioning

confidence: 99%

Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure

Liu

Cao

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Severe Plasmodium vivax infection in Korea

Kwon

Baek

et al. 2017

Malar J

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BackgroundAlthough severe malaria by Plasmodium vivax has been increasingly reported, there are marked variations in the type and rate of the complications by geographic area. This is possibly because of the presence of concurrent falciparum malaria or bacteraemia, and of differences in underlying immune status among the infected subjects. Furthermore, published studies on P. vivax in temperate regions are limited. The present study investigated severe vivax malaria in Korea, where only vivax malaria occurs. Hence, other compounding factors are rare. Additionally, most of the patients are possibly non-immune to this malarial disease.MethodsAdults with vivax malaria observed in one 860-bed university hospital from January 2006 to December 2012 were retrospectively evaluated. Seventeen patients who had travelled overseas within 6 months before the presentation of malaria were excluded. Severe vivax malaria was diagnosed according to World Health Organization criteria. Other complications were also investigated.ResultsTwo-hundred and ten patients were enrolled, of which 88 (41.9%) were treated as inpatients and the remainder as outpatients. Eleven patients were treated in an intensive care unit; among them, five patients received mechanical ventilation, and one needed extracorporeal membrane oxygenation therapy (ECMO) additionally. Severe vivax malaria was identified in 44 patients (21.0%), and the most common severe complication was pulmonary manifestation (40/188, 21.9%), which was followed by cerebral malaria (5/210, 2.4%), shock (4/210, 1.9%), spontaneous bleeding (3/210, 1.4%), metabolic acidosis (3/210, 3.5%) and acute kidney injury (2/210, 1.0%). Unusual complications, such as splenic infarction (ten patients) and retinal haemorrhage (two patients) were sometimes observed. There were no deaths, but the case involving ECMO was potentially fatal.Conclusions Plasmodium vivax infection can be severe to be fatal and is frequently associated with various complications in non-immune adults. The frequency of each complication seems to differ from other countries. Hence, further investigation is needed to elucidate the causes and mechanisms responsible for these differences.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-017-1684-4) contains supplementary material, which is available to authorized users.

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Bilateral Facial Palsy: Post Vivax Malaria Scenario

Sawardekar¹,

Patil²,

Badgujar³

et al. 2016

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Malaria can cause severe complications, sometimes affecting central nervous system. Cranial nerve palsies are rare after malaria. Plasmodium vivax malaria, often thought to be a benign disease can sometime lead to severe complications. We report a case of lower motor neuron palsy after plasmodium vivax malaria. KEYWORDSFacial Palsy, Vivax Malaria. HOW TO CITE THIS ARTICLE: INTRODUCTIONMalaria is a common health problem in tropical countries like India. Of the four plasmodium species causing malaria in humans, P. vivax is the most widespread. P. vivax malaria in India is more prevalent than plasmodium falciparum. 1 In India P. vivax and P. falciparum accounts for about 60-65% and 35% cases respectively. 2 P. vivax is often thought to be benign infection; however, it may sometime result in severe complications affecting different organs. 3 Commonly reported severe complications of P. vivax malaria include haematological problems, such as anaemia and thrombocytopenia, liver or kidney dysfunction, lung related complications, hypoglycaemia, shock and cerebral malaria. 2,3 We report here an unusual case of bilateral lower motor neuron palsy after P. vivax malaria.

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Acute pancreatitis, ascites, and acute renal failure in Plasmodium vivax malaria infection, a rare complication

Cited by 4 publications

References 10 publications

Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure

Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure

Severe Plasmodium vivax infection in Korea

Bilateral Facial Palsy: Post Vivax Malaria Scenario

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