Acute pancreatitis associated with Cushing syndrome – A case report and literature review

Bouali, Mounir; Sylvestre, K.; Bakouri, Abdelilah El; Hattabi, Khalid El; Bensardi, Fatimazahra; Fadil, Abdelaziz

doi:10.1016/j.amsu.2021.102260

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…In our study, one case suffered from acute pancreatitis and was under life-threatening situation. Previously, only one case [10] reported acute pancreatitis complicated in non-pregnant women with Cushing's syndrome. It's di cult to illustrated a potential association between adrenal adenoma and acute pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center

Zhu

Cai

Zhang

et al. 2023

Preprint

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Background Adrenal adenoma during pregnancy is rare and the diagnosis is challenging owing to unspecific symdromes and restricted investigation. It’s poorly described obstetric outcomes of patients underwent surgery during pregnancy or only received medicine treatment. To report the clinical characteristics and obstetric outcomes of pregnant women complicated with adrenal adenoma. Methods A retrospective study was performed. The clinical characteristics, management and obstetric outcome of pregnancies diagnosed as adrenal adenoma over 20 years were reviewed from a teriary hospital. Results A total of 12 women were diagnosed as adrenal adenoma during pregnancy from to January 2000 to September 2022. Eight women had cortisol-secreting adrenal adenoma, two had over-secrete catecholamine and two primary aldosteronism. The original symptoms adrenal adenoma during pregnancy included hypertension or preeclampsia, gestational diabetes mellitus or pre-pregnancy diabetes mellitus, hypokalemia and ecchymosis. There were four women took adrenalectomy during pregnancy, while 8 women only received medicine therapy. Preterm birth occurred in all cases who received medicine, whereas 1 case suffered from preterm birth in the group underwent surgery. Among the 8 women of medicine group, there were 3 neonatal death. Conclusions Once simultaneous onset of hypertension, hyperglycemia and hypokalemia during the 1st or 2nd trimester, adrenal adenoma should be investigate by laboratory examination and imaging examination. The maternal and fetal outcome were unpredictive owing to the severity of adrenal adenoma, particular in patients only received medicine treatment. Adrenalectomy should be recommended during the pregnancy.

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Section: Discussionmentioning

confidence: 99%

Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center

Zhu

Cai

Zhang

et al. 2023

Preprint

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“…16 In addition, propofol produced acute pancreatitis in adult and children, both with underlying diseases (sepsis, Cushing disease, and severe burn) (Table 2), which may be associated with pancreatitis, and/or concomitant administration of other potential drugs. 17–19 The time interval (total patients = 17) between propofol infusion and acute pancreatitis in the reported cases was less than 24, 24–48, and 49–72 hours and more than 72 hours, in 9, 3, 1, and 4 cases, respectively (Table 2).…”

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confidence: 94%

Confounding Factors Associated With Propofol-Induced Acute Pancreatitis: A Review

Kim

Sohn

2021

American Journal of Therapeutics

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However, FSGS because of IFN-b is an exceedingly rare occurrence. On review of literature, 12 cases were encountered. Among them, 10 were Black, 8 female, 8 hypertensives, and 3 were obese. 2,6,[11][12][13][14] Also, 4 of the cases were patients with MS on interferon treatment. 2,6,11,13,15 Our case demonstrates some similarities to those reported as our patient was a woman. However, our patient was a White with a normal body mass index and not diagnosed with hypertension. Using the Naranjo criteria questionnaire for determining the likelihood of whether an adverse drug reaction is actually due to the drug, our patient scores a 6, implying it is probable. 16 Our patient was similar to 5 other reported cases where the symptoms resolved after stopping interferon, starting steroids, and immunomodulators. Moreover, they also had their renal function returned to baseline and complete laboratory remission. 2,[11][12][13] This case represents a rare adverse effect of INF-b in MS. Physicians should draw attention to symptoms and findings of nephropathy during IFN-b therapy, as routine work-up do not include renal function tests and urinalysis.

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Pregnancies complicated with functioning adrenal adenomas causing severe obstetric outcomes: a 20-year experience at a tertiary center

Zhu,

Cai,

Zhong

et al. 2024

BMC Endocr Disord

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Background Functioning adrenal adenoma during pregnancy is rare, and the diagnosis is challenging owing to unspecific symptoms and restricted investigations. The obstetric outcomes of patients who undergo surgery during pregnancy or who receive only medical treatment are poorly described. Objective The aim was to investigate the associations between functioning adrenal adenomas and obstetric outcomes. Methods A retrospective study was performed in a tertiary center over 20 years. The clinical characteristics, management and obstetric outcomes of the diagnosed pregnant women were reviewed. Results A total of 12 women were diagnosed with functioning adrenal adenomas during pregnancy from January 2002 to September 2022. Eight women had cortisol-secreting adrenal adenomas, two had excessive catecholamine secretion, and two had primary aldosteronism. The initial symptoms of adrenal adenoma during pregnancy included hypertension or preeclampsia, gestational diabetes mellitus or prepregnancy diabetes mellitus, hypokalemia and ecchymosis. Four women underwent adrenalectomy during pregnancy, while 8 women received only medical therapy. Preterm birth occurred in all patients who received medicine, whereas 1 patient who underwent surgery experienced preterm birth. Among the 8 women in the medical treatment group, 3 had neonates who died. Conclusions Once hypertension, hyperglycemia and hypokalemia occur during the 1st or 2nd trimester, pregnant women with adrenal adenomas should be evaluated via laboratory and imaging examinations. The maternal and fetal outcomes were unpredictable owing to the severity of adrenal adenoma, particularly in patients who received only medical treatment. Adrenalectomy should be recommended during pregnancy.

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Acute pancreatitis associated with Cushing syndrome – A case report and literature review

Cited by 4 publications

References 16 publications

Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center

Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center

Confounding Factors Associated With Propofol-Induced Acute Pancreatitis: A Review

Pregnancies complicated with functioning adrenal adenomas causing severe obstetric outcomes: a 20-year experience at a tertiary center

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