Acute pancreatitis caused by bortezomib

Solakoğlu, Tevfik; Akyol, Pınar Yeşim; Guney, Tekin; Dılek, İmdat; Atalay, Roni; Köseoğlu, Hüseyin; Akın, Ebru; Bolat, Aylin Demirezer; Büyükaşık, Naciye Şemnur; Ersoy, Osman

doi:10.1016/j.pan.2013.01.002

Cited by 13 publications

(14 citation statements)

References 7 publications

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“…Recognition of the failure of inadequate UPR to relieve ER stress as an initiation fact of acinar cell injury in AP can make clinicians more cautious of using the medications that impair the UPR in patients with AP risk. For example, Bortezomib, an ERAD inhibitor used in the treatment of patients with multiple myeloma, induced AP[ 78 ].…”

Section: Upr and Ap Managementmentioning

confidence: 99%

Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis

Barrera

Stanek

Okochi

et al. 2018

WJGP

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Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response (UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum (ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR’s signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB’s pro-inflammatory activity and impair autophagy’s protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP.

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Section: Upr and Ap Managementmentioning

confidence: 99%

Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis

Barrera

Stanek

Okochi

et al. 2018

WJGP

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“…Bortezomib pancreatitis is a rare but potentially serious complication, 4 so it is important to consider it in patients receiving this treatment. The diagnosis is based on exclusion of the most common causes of pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Management of pancreatitis related to Bortezomib treatment: report of two cases

Brulc

Seehaus

Schütz

et al. 2018

Hematology, Transfusion and Cell Therapy

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“…This presentation was similar to the cases reported in literature previously, where pancreatitis was the first clinical manifestation, and later on multiple myeloma was detected. Pancreatitis has been rarely reported in association with multiple myeloma, and in most of the cases, the cited reason was hypercalcemia [2,3], initiation of chemotherapy [4,5], or direct infiltration of pancreas by plasma cells [6,7]. Multiple myeloma is usually associated with hypercalcemia and incidence of hypercalcemia is about 30% in cases of multiple myeloma [8].…”

Section: Discussionmentioning

confidence: 99%

“…ccording to the literature available, very few cases of pancreatitis in association multiple myeloma have been reported [1][2][3][4][5]. The most common cause being hypercalcemia induced pancreatitis and incidence of hypercalcemia is about (30%) in cases of multiple myeloma.…”

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confidence: 99%

Multiple Myeloma Presenting With Acute Pancreatitis and Renal Failure

Mishra

Patil²,

Bansal³

et al. 2017

IJCR

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Multiple myeloma is the disease of elderly male with medullary and extramedullary involvement. Pancreatitis is rarely reported in such cases. Here, we report a case of an elderly male who presented with a clinical picture of acute pancreatitis and when investigated, was found to have multiple myeloma and acute renal failure. He was further evaluated for various causes of pancreatitis and was finally concluded to have a possibility of a direct invasion of pancreas by plasma cells.

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Acute pancreatitis caused by bortezomib

Cited by 13 publications

References 7 publications

Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis

Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis

Management of pancreatitis related to Bortezomib treatment: report of two cases

Multiple Myeloma Presenting With Acute Pancreatitis and Renal Failure

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