Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation

Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin

“…It has also been linked to disease pathology; for example, in the heart, the activation of calcineurin produces cardiac hypertrophy (15). There have been conflicting reports from both clinical and experiment studies about the role of calcineurin in pancreatitis (7,19,24,26,34). However, there is some evidence in acinar cells suggesting that NF-B activation is dependent on calcineurin (14).…”

Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin

“…An explanation for this is that calcineurin inhibition or deficiency at base line may prevent the homeostatic mechanisms that preserve the normal architecture of the pancreatic parenchyma. There are a few case reports suggesting a clinical association of FK506 use with pancreatitis (67)(68)(69)(70)(71). However, there is considerable disparity in the experimental literature.…”

Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury

“…It is important to note, however, that the Cn inhibitors were given for brief periods before or during the induction of acinar cell injury. However, chronic administration of Cn inhibitors exacerbates pancreatitis or pancreatic fibrosis in several clinical (37,46) and experimental reports (6,12,47).…”