Acute pancreatitis in Chile: A multicenter study on epidemiology, etiology and clinical outcome. Retrospective analysis of clinical files

Berger, Zoltán; Mancilla, Carla; Tobar, Eduardo; Morales, María Paz; Baró, Michel; Carrasco, Mauricio; Cordero, J L; Cruz, Raúl; Cruz, Ricardo Pedrini; Lara, Christián; Ledesma, Sergio; Ramírez, Gustavo; Sierralta, Armando; Godoy, Luís Filipe de Souza; Valdés, Eliana

doi:10.1016/j.pan.2020.04.016

Cited by 24 publications

(22 citation statements)

References 30 publications

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“…The incidence of AP is about 13-45/100,000 among the general population. 1,2 In most patients, the course is selflimiting, 20~30% of patients face a perilous clinical experience, and the overall mortality rate is 5~10%. 1,3 The incidence of acute pancreatitis in pregnancy (APIP) is higher than the prevalence among the general population, which is about 1/1000-1/12,000.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Admission Serum Triglyceride Level on the Prediction of Severity of Acute Pancreatitis in Pregnancy

Sheng¹,

Wang²,

Xu³

et al. 2021

RMHP

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Purpose: Previous studies indicated that the serum triglyceride level in patients with acute pancreatitis positively correlated with the severity of the disease among the general population. Despite the physiological hypertriglyceridemia in pregnant women, there are no reports on the relationship between serum triglyceride level and the severity of acute pancreatitis in pregnant (APIP) women. This study explores the relationship between serum triglyceride levels and the severity of APIP. Patients and Methods: Clinical information of APIP patients admitted to the Shengjing Affiliated Hospital of China Medical University was gathered from January 2012 to December 2020 to conduct retrospective research. The participating patients were divided into mild, moderately severe, and severe acute pancreatitis. The clinical outcomes of patients with different serum triglyceride levels (0-2.3 mmol/L, 2.23-5.65 mmol/L, 5.65-11.2 mmol/ l, ≥11.2 mmol/L) were analyzed by performing ordinal logistic regression analysis. Receiver operating curve analysis was used to calculate the threshold value of serum triglyceride concentration that can effectively predict the occurrence of severe acute pancreatitis (SAP). Results: Hypertriglyceridemic acute pancreatitis (HTG-AP) occurred in 47% of APIP patients within the group, with a high prevalence among the Han population. In the present study, the serum triglyceride concentration correlated positively with the severity of APIP (r=0.403, P < 0.05). The adjusted logistic model demonstrated that relative to nominal triglyceride levels, the OR value of SAP were 1.036 (95% CI: 0.401-2.677), ) with triglyceride at the level of 2.23-5.65 mmol/L, 5.65-11.2 mmol/l and ≥11.2 mmol/L. In APIP patients, a triglyceride concentration of 10.7mmol/L or more upon admission was a predictive value for the occurrence of SAP, with a sensitivity of 0.72 and a specificity of 0.65, AUC: 0.708 (95% CI: 0.620-0.796). Conclusion:As the serum triglyceride level upon admission increased, the frequency of local and systemic complications increased significantly.

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Section: Introductionmentioning

confidence: 99%

The Effect of Admission Serum Triglyceride Level on the Prediction of Severity of Acute Pancreatitis in Pregnancy

Sheng¹,

Wang²,

Xu³

et al. 2021

RMHP

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“…El único dato previo es el de Berger y cols 11 , quienes mencionan una tasa de PA de 40 x 100.000 habitantes, cifra muy similar al nuestra. En el resto de Sudamérica hay pocos datos epidemiológicos 13 .…”

Section: Discussionunclassified

“…Un hallazgo destacable fue el comportamiento epidemiológico de la PA a lo largo de Chile con diferencias significativas entre 7 regiones del "Norte-Centro" comparados con 8 regiones del "Centro-Sur". Este hecho fue señalado por Berger y cols 11 , al notar que en la comuna de Angol (Grupo 2 de nuestro estudio), la tasa de PA era de 57 x 100.000 habitantes. Además, observamos que 7 de las 8 regiones del Grupo 2 tienen mayores tasas que cualquiera del Grupo 1.…”

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Epidemiología de la pancreatitis aguda en Chile entre los años 2013 y 2018

2021

Rev. méd. Chile

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“…The overall mortality of AP is 2.5 -7.5% but increases to 30 to 45% in SAP. [1][2][3] There are many scoring systems to predict SAP. Acute Physiology and Chronic Health Evaluation II (APACHE II) used in intensive care unit which is time-consuming, Ranson score which requires 48 hours and multiple laboratory parameters, and Bedside Index for Severity in Acute Pancreatitis (BISAP) which is mainly used to predict mortality in AP.…”

Section: Introductionmentioning

confidence: 99%

Utility of Neutrophil to Lymphocyte ratio and platelet to lymphocyte ratio as early predicter of severe acute biliary pancreatitis

Shah¹,

Paudyal²,

Maharjan³

et al. 2021

Nep. Med. J.

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Introduction: Acute severe pancreatitis is associated with increased mortality. Several scoring systems have been used to predict severe acute pancreatitis which are either time-consuming or calculated 48 hours after admission. This study was aimed to assess the utility of neutrophils to lymphocyte ratio and platelet to lymphocyte ratio as an early predictor of severe acute biliary pancreatitis.Materials and Methods: This was a retrospective cohort study conducted from January 2017 to January 2020. Patients with non-biliary pancreatitis, referred after initial treatment, missed data, and acute pancreatitis with acute cholecystitis or cholangitis were excluded from the study. Data were collected from case sheets. Patients were divided into two groups according to the development of severe acute biliary pancreatitis based on the revised Atlanta Classification. Association of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with severe acute biliary pancreatitis was assessed using Mann Whitney U-test. p-value < 0.05 was considered as statistically significant.Results: Total 73 cases included in the study (males/females= 0.55). Sixty-six patients (90.4%) had mild/moderate acute biliary pancreatitis, and 7 (9.6%) patients had severe acute biliary pancreatitis. There was a development of complications in 7 (9.6%) patients who had severe acute biliary pancreatitis including one mortality. The mean neutrophil to lymphocyte ratio and mean platelet to lymphocyte ratio were high in the severe acute biliary pancreatitis group compared to the nonsevere acute biliary pancreatitis group, however, these differences were not statistically significant.Conclusions: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio cannot predict severe acute biliary pancreatitis.

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Acute pancreatitis in Chile: A multicenter study on epidemiology, etiology and clinical outcome. Retrospective analysis of clinical files

Cited by 24 publications

References 30 publications

The Effect of Admission Serum Triglyceride Level on the Prediction of Severity of Acute Pancreatitis in Pregnancy

The Effect of Admission Serum Triglyceride Level on the Prediction of Severity of Acute Pancreatitis in Pregnancy

Epidemiología de la pancreatitis aguda en Chile entre los años 2013 y 2018

Utility of Neutrophil to Lymphocyte ratio and platelet to lymphocyte ratio as early predicter of severe acute biliary pancreatitis

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