Acute Pancreatitis in Chronic Dialysis Patients

Barbara, Mary; Tsen, Adrianne; Rosenkranz, Laura

doi:10.1097/mpa.0000000000001119

Cited by 17 publications

(7 citation statements)

References 28 publications

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“…In parallel with the literature, the mortality rate among our severe acute pancreatitis patients according to BISAP scoring was signifi cantly higher than that among mild acute pancreatitis patients. It has been reported in many studies that the parameters used in the BISAP scoring, such as high BUN, presence of pleural effusion, age of 60 or over, and presence of SIRS criteria increase the mortality rate of acute pancreatitis (11,12). In a study by Arif et al, the Ranson and BISAP scores were compared for detecting severe acute pancreatitis with an accuracy rate of 82.0 % for the Ranson score and 76.2 % for the BISAP score (1).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the predictive values of CRP, CRP/albumin, RDW, neutrophil/lymphocyte, and platelet/lymphocyte levels in determining the severity of acute pancreatitis in patients with acute pancreatitis according to the BISAP score

Karabuga¹,

Gemcioğlu²,

Karabuga³

et al. 2022

BLL

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BACKGROUND: In our study, it was aimed to fi nd out whether it would be possible to determine the disease severity by comparing the values of red cell distribution width (RDW), c-reactive protein (CRP), CRP/albumin, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with acute pancreatitis according to Bedside Index of Severity in Acute Pancreatitis (BISAP) scores at the time of admission. METHODS: Five hundred patients diagnosed with acute pancreatitis were included in the study. RESULTS: According to BISAP scores, 388 (77.6 %) patients were evaluated as having mild acute pancreatitis and 112 (22.4 %) patients as having severe acute pancreatitis. In ROC analysis, values of 70.54 % sensitivity and 70.10 % specifi city for CRP, 71.43 % sensitivity and 70.88 % specifi city for CRP/albumin, 80.36 % sensitivity and 30.30 % specifi city for RDW, 75.00 % sensitivity and 43.98 % specifi city for NLR, and 55.36 % sensitivity and 38.51 % specifi city for PLR were determined. Values of 85.71 % sensitivity and 66.49 % specifi city were determined for the NLR-CRP/Albumin-RDW 2** score as a newly created scoring system. CONCLUSION: CRP/albumin, NLR, PLR, and RDW values were found to be statistically signifi cantly higher in patients with severe acute pancreatitis compared to those with mild acute pancreatitis according to the BISAP score (p<0.001). In comparison to previous studies in the literature, similar sensitivity and specifi city values were obtained in determining the severity of the disease with the new NLR-CRP/Albumin-RDW 2** score, and it is thought that this scoring system could be a practical and reliable guide in the treatment and follow-up of patients with acute pancreatitis

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Section: Discussionmentioning

confidence: 99%

Comparison of the predictive values of CRP, CRP/albumin, RDW, neutrophil/lymphocyte, and platelet/lymphocyte levels in determining the severity of acute pancreatitis in patients with acute pancreatitis according to the BISAP score

Karabuga¹,

Gemcioğlu²,

Karabuga³

et al. 2022

BLL

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“…1,2 The incidence rate of AP ranges from 4.9 to 73.4 per 100,000 people per year worldwide. 3 Most cases of AP in developed countries are mainly attributable to gallstone disease and alcohol abuse. 4 Acute lung injury is a common AP-associated multiple organ dysfunction.…”

Section: Introductionmentioning

confidence: 99%

<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>

Gao¹,

Sui²,

Fan³

et al. 2020

DDDT

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Lung injury is a common complication of acute pancreatitis (AP), which leads to the development of acute respiratory distress syndrome and causes high mortality. In the present study, we investigated the therapeutic effect of emodin on AP-induced lung injury and explored the molecular mechanisms involved. Materials and Methods: Thirty male Sprague-Dawley rats were randomly divided into AP (n=24) and normal (n=6) groups. Rats in the AP group received a retrograde injection of 5% sodium taurocholate into the biliary-pancreatic duct and then randomly assigned to untreated, emodin, combined emodin and ML385, and dexamethasone (DEX) groups. Pancreatic and pulmonary injury was assessed using H&E staining. In in vitro study, rat alveolar epithelial cell line L2 cells were exposed to lipopolysaccharide and treated with emodin. Nrf2 siRNA pool was applied for the knockdown of Nrf2. The contents of the pro-inflammatory cytokines in the bronchoalveolar lavage fluid and lung were determined using enzyme-linked immunosorbent assay. The expressions of related mRNAs and proteins in the lung or L2 cells were detected using real-time polymerase chain reaction, Western blot, immunohistochemistry and immunofluorescence. Key Findings: Emodin administration alleviated pancreatic and pulmonary injury of rats with AP. Emodin administration suppressed the production of proinflammatory cytokines, downregulated NLRP3, ASC and caspase-1 expressions and inhibited NF-κB nuclear accumulation in the lung. In addition, Emodin increased Nrf2 nuclear translocation and upregulated HO-1 expression. Moreover, the anti-inflammatory effect of emodin was blocked by Nrf2 inhibitor ML385. Conclusion: Emodin effectively protects rats against AP-associated lung injury by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.

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“…In addition to the foregoing, dialysis patients face additional risks, such as hypotension during hemodialysis, which can lead to ischemia–reperfusion injury. Repeated peritonitis episodes put peritoneal dialysis patients at risk, and peritoneal dialysis fluid components including calcium and glucose predispose them to pancreatitis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

COVID 19 induced acute pancreatitis in patients with renal impairment: report of five cases

Tadkal

Siddini

Augustine

et al. 2022

Clin J Gastroenterol

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COVID 19 infection is an ongoing pandemic that the world is facing currently. Though SARS-CoV2 infection mainly involves the lungs, it is known to affect other organs like kidneys, brain, heart, endocrine organs and gastrointestinal system. It is hypothesized that the ACE2 and transmembrane serine protease 2 which are expressed in the beta cells of the pancreas are the entry receptors for the SARS-CoV-2 virus, thus causing pancreatitis. A retrospective review of clinical records at our institution during the COVID 19 pandemic from 2019 to 2020 was carried out to find patients with COVID 19 infection presenting with acute pancreatitis. Additionally, a review of literature was conducted about COVID 19 patients presenting with pancreatitis in chronic kidney disease and renal transplantation recipients. Five patients with COVID 19 infection presented with acute pancreatitis during the 2019–2020 pandemic period. All patients were males and mean age of the patients was 48 ± 20 years. Out of 5 patients, 3 were chronic kidney disease patients, 2 were renal transplantation recipients. COVID 19 infection was the cause of acute pancreatitis in all 5 cases. Out of 5, 1 patient had acute necrotizing pancreatitis and the rest had mild to moderate severity pancreatitis. All patients recovered except the patient with acute necrotizing pancreatitis who succumbed to the illness. One patient with chronic kidney disease became dialysis dependent post recovery from pancreatitis. In all 5 patients, there was no correlation between the severity of COVID ARDS and the severity of pancreatitis. There was no correlation between the severity of pancreatitis and the elevation of inflammatory markers. In patients presenting with pancreatitis, we have to keep in mind COVID 19 infection along with other known aetiologies of acute pancreatitis. Supplementary Information The online version contains supplementary material available at 10.1007/s12328-022-01633-5.

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Acute Pancreatitis in Chronic Dialysis Patients

Cited by 17 publications

References 28 publications

Comparison of the predictive values of CRP, CRP/albumin, RDW, neutrophil/lymphocyte, and platelet/lymphocyte levels in determining the severity of acute pancreatitis in patients with acute pancreatitis according to the BISAP score

Comparison of the predictive values of CRP, CRP/albumin, RDW, neutrophil/lymphocyte, and platelet/lymphocyte levels in determining the severity of acute pancreatitis in patients with acute pancreatitis according to the BISAP score

<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>

COVID 19 induced acute pancreatitis in patients with renal impairment: report of five cases

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