Acute Pancreatitis in Patients on Chronic Peritoneal Dialysis: An Increased Risk?

Quraishi, Essam; Goel, Sachin S.; Gupta, Mini; Catanzaro, Andrew; Zasuwa, B.S. Gary; Divine, George

doi:10.1111/j.1572-0241.2005.41646.x

Cited by 39 publications

(32 citation statements)

References 21 publications

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“…Several studies confirmed the higher incidence of AP in patients receiving PD, either in comparison to HD patients or in the general populations [3], [4]. For patients receiving PD, it has been hypothesized that both elevated abdominal pressure during PD and a non-physiological composition solution may contribute to premature proteolytic enzymes activation, leading to an AP attack [3].…”

Section: Discussionmentioning

confidence: 92%

Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: A 4-Year Follow-Up Study

Hou¹,

Lee

Hsu

et al. 2013

PLoS ONE

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BackgroundThe risk of acute pancreatitis in patients on long-term peritoneal dialysis is higher as compared to the general population. However, the relationship between long-term hemodialysis and acute pancreatitis has never been established.ObjectivesWe investigated the incidence of acute pancreatitis among patients on long-term hemodialysis in Taiwan to evaluate if there is a higher risk of acute pancreatitis in comparison to the general population.MethodsWe utilized a National Health Insurance (NHI) claims data sample containing one million beneficiaries. We followed all adult beneficiaries from January 1, 2007 until December 31, 2010 to see if they had been hospitalized for acute pancreatitis during this period. We further identified patients on chronic hemodialysis and compared their risk of acute pancreatitis with the general population.ResultsThis study included 2603 patients with long-term hemodialysis and 773,140 patients without hemodialysis. After controlling for age, gender, Charlson Comorbidity Index Score, geographic region, socioeconomic status and urbanization level, the adjusted hazard ratio was 3.44 (95% Confidence interval, 2.5–4.7).ConclusionsThe risk of acute pancreatitis in patients on long-term hemodialysis is significantly higher in comparison to the general population.

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Section: Discussionmentioning

confidence: 92%

Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: A 4-Year Follow-Up Study

Hou¹,

Lee

Hsu

et al. 2013

PLoS ONE

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“…Pancreatitis is a well-recognized complication of this disease, and its frequency appears to be related to the type of dialysis. In one US study, the incidence of acute pancreatitis was 18.4 per 1000 personyears in patients receiving peritoneal dialysis and 6.5 per 1000 person-years in those receiving hemodialysis [26]. A survey of German patients observed a similar excess in patients receiving peritoneal dialysis [27].…”

Section: Additional Causesmentioning

confidence: 97%

The changing character of acute pancreatitis: Epidemiology, etiology, and prognosis

Lowenfels

Maisonneuve²,

Sullivan³

2009

Curr Gastroenterol Rep

188

109

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Acute pancreatitis continues to be a diagnostic and therapeutic challenge for physicians and surgeons. It ranks third in the list of hospital discharges for gastro-intestinal diseases. In most patients the cause is either gallstones or alcoholism. The overall mortality is less than 5%, but severe acute pancreatitis leads to prolonged hospitalization and much higher mortality. There are important differences in disease susceptibility and case fatality rates: the incidence is higher in blacks than in whites, and mortality is higher in older patients than in younger patients. Reports from various countries reveal that the frequency of acute pancreatitis is increasing, perhaps in relation to rising obesity rates, which would increase the likelihood of gallstone pancreatitis. Conversely, mortality rates for acute pancreatitis are declining in many, but not all, reports.

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“…6 "Local hypercalcemia" in the pancreas due to calcium in the PD solution has also been postulated. 7 Increase in various gastrointestinal hormones such as cholecystokinin, gastric inhibitory polypeptide, and glucagon in patients with CKD can stimulate hypersecretion of pancreatic enzymes such as trypsin which can contribute to impairment in pancreatic function. 8 There is also this unique situation of coexistence of peritonitis and pancreatitis in patients who are on CAPD.…”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis in Chronic Kidney Disease—A Common but Often Misunderstood Combination

Golay

Roychowdhary

2012

Renal Failure

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The occurrence of pancreatitis has been reported among chronic kidney disease (CKD) patients, especially those who are on peritoneal dialysis. It contributes to an increased morbidity and mortality in patients who are already suffering from renal failure. The diagnosis of acute pancreatitis is also modified by the loss of renal function with altered levels of pancreatic enzyme estimation and the contribution of pancreatic damage due to uremia and dialysis. We describe two cases of CKD who presented with acute pancreatitis and also briefly review the literature.

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Acute Pancreatitis in Patients on Chronic Peritoneal Dialysis: An Increased Risk?

Abstract: PD is a risk factor for AP. There is no statistical difference in AP-related mortality and morbidity between HD and PD.

Cited by 39 publications

References 21 publications

Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: A 4-Year Follow-Up Study

Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: A 4-Year Follow-Up Study

The changing character of acute pancreatitis: Epidemiology, etiology, and prognosis

Acute Pancreatitis in Chronic Kidney Disease—A Common but Often Misunderstood Combination

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