Acute Pancreatitis – Update 2006

Arbuckle, James; Isla, Alberto

doi:10.1007/978-3-540-32784-4_20

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Positive prognostic findings based on clinical evaluation systems for pancreatitis such as Ranson and Glasgow are used to predict potential morbidity and mortality [6]. These scoring systems are relatively successful in determining the disease progression; nevertheless, for an accurate evaluation, 48 hours should be completed.…”

Section: Discussionmentioning

confidence: 99%

“…Early diagnosis and staging are main objectives in the initial evaluation and treatment of pancreatitis in patients with AP to differentiate those with severe disease and to establish proper treatment [6]. Clinical and laboratory studies have been conducted on numerous markers of pancreatitis as potential prognostic indicators; however, except a few, none have been commonly used in clinical practice [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Severity markers in patients with acute pancreatitis

et al. 2014

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AbstractTo evaluate the effectiveness of serum levels of resistin and CD14 expression in monocytes, and high-sensitivity C-reactive protein (hsCRP) in early stages of acute pancreatitis and correct prediction of the severity of acute pancreatitis (AP) using scoring systems. The study involved 10 (29.41%) male and 24 (70.59%) female patients (total n=34) followed for AP diagnosis at the Department of General Surgery, Ataturk University Medical School between July 2008 and September 2009. In all the patients, Ranson and APACHE II scores, serum resistin, hsCRP, and monocyte CD14 expression levels were determined. The patients were divided into two groups as mild and severe AP groups. A control group was formed and the intergroup comparisons were made. Values ≥ 3 based on the Ranson scoring scale and values ≥ 8 in APACHE II scoring scale were considered to indicate severe AP. Evaluations were based on the values obtained on the 1st and 7th days for serum resistin and hsCRP levels and monocyte CD 14 expression. In 17 (50%) patients, severe AP was determined. No statistically significant differences were found between the mean serum resistin levels of AP groups, while the difference for the same parameter between the mild and severe AP groups and the control group was statistically significant. In the severe AP group, the mean 1st day and 7th day serum hsCRP levels were statistically significantly higher. The CD14 expression in monocytes was similar in all the groups. Serum hsCRP concentrations and Ranson and APACHE II scores and serum resistin and hsCRP concentrations on the 1st day were positively correlated. Serum hsCRP measurement is effective in determining the severity of acute pancreatitis. Serum resistin measurement may be a useful early marker in determining the inflammatory response in AP. However, CD14 expression in monocytes was not found to be a useful marker in the diagnosis and prediction of the disease severity in AP patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Severity markers in patients with acute pancreatitis

et al. 2014

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“…[5][6][7][8] Early diagnosis and staging are main objectives in the initial evaluation, to differentiate those with severe disease and to establish proper treatment. 9 Recent critical care data have indicated that the median length of stay for patients with acute pancreatitis before transferring to intensive care was 1 day. 10 Therefore, the first 24 hours of hospitalization represents a critical "therapeutic window" during which efforts should be made to identify patients at increased risk of severe disease to provide optimal therapy.…”

Section: Introductionmentioning

confidence: 99%

Blood urea nitrogen as an early predictor of severity in acute pancreatitis

et al. 2021

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Background: Acute pancreatitis presents as acute abdominal pain and is usually associated with raised pancreatic enzyme levels in the blood or urine. Aims and objectives of the study was to evaluate the role of serial BUN measurement as an early prognostic marker of acute pancreatitis.Methods: From each patient detailed history was taken, general and systemic examination were done and relevant investigations were conducted. BUN was repeated after 24 hours and the change in the level of BUN was noted. Imaging in the form of CT after 72 hours of admission were performed in each patient. The severity of acute pancreatitis was gauged by modified CTSI and the same was compared to the change in BUN values over first 24 hours of admission.Results: Mean BUN values at ‘0’ hour in severe acute pancreatitis and non-severe acute pancreatitis were 31.91±6.79 and 15.44±5.95 mg/dl, respectively. The difference between the two groups was statistically significant with p value of <0.001. Similarly, the difference in BUN values at ‘24’ hours between the two groups was statistically significant. BUN value ≥23 mg/dl at ‘0’ hour was found to be the optimal cut off for determining the severity of pancreatitis with sensitivity of 91.3%. BUN ≥25 mg/dl at 24 hours was found to be the optimal cut-off for determining the severity of acute pancreatitis with sensitivity of 95.7%.Conclusions: BUN as a single marker for acute pancreatitis can be useful as it is easy to perform and cheap marker to predict severity without the need for complex calculations.

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