Acute pericarditis: A peculiar manifestation of common variable immune deficiency

Ramzi, Nasim; Yazdani, Shahrooz; Talakoob, Hamed; Karim, Hossein; Jamee, Mahnaz; Azizi, Gholamreza

doi:10.15586/aei.v49i3.99

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Both cases are associated with non-compliance with Ig therapy, which can point to a protective role against pyopericardium. Unlike our patient, the outcome was poor, with death at the age of 13 from respiratory distress and pneumonia 7…”

Section: Discussioncontrasting

confidence: 77%

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Pyopericardium presenting as pericardial tamponade in a patient with common variable immunodeficiency disorder

Windels,

Neri,

Conceição

et al. 2023

BMJ Case Rep

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A male patient in his 20s with a medical history of common variable immunodeficiency disorder, non-compliant with therapy, presented to the emergency department with respiratory distress and severe hypoxaemia. Chest radiography demonstrated extensive bilateral infiltrates and an increased cardiothoracic ratio.Streptococcus pneumoniaeurine antigen test was positive. ECG demonstrated diffuse ST-segment elevation. An arterial line was placed and demonstrated pulsus paradoxus. Transthoracic echocardiography revealed an extensive pericardial effusion, with echocardiographic signs of cardiac tamponade. Emergency subxiphoid pericardiocentesis was performed with an initial drainage of 750 mL of purulent fluid consistent with pyopericardium. Immediate haemodynamic improvement was observed. The patient required a second pericardiocentesis for drainage of a relapsing pericardial effusion. The course was complicated by effusive-constrictive pericarditis requiring anterior interphrenic pericardiectomy. Treatment with intravenous immunoglobulin and antibiotics led to a complete recovery.

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Section: Discussioncontrasting

confidence: 77%

“…Reviewing the literature, we only found seven cases of pericardial diseases in patients with CVID. One case of pericardial tamponade due to primary effusion lymphoma, one case of pericardial effusion of unknown aetiology and one article reporting five cases of acute pericarditis, with only one patient with pneumococcal pericarditis 5–7…”

Section: Introductionmentioning

confidence: 99%

Pyopericardium presenting as pericardial tamponade in a patient with common variable immunodeficiency disorder

Windels,

Neri,

Conceição

et al. 2023

BMJ Case Rep

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“…Thirdly, this study only included RCT, which can compare ICI with non ICI, dual drug ICI with single drug ICI. Despite existing statistics, it is still not possible to comprehensively evaluate the CAE risk of these patients, and some studies only report a specific CAE risk ( 31 , 32 ). In RCT, due to the strict requirements of the trial protocol, the trial needs to be discontinued in the event of severe cardiotoxicity, so very fewer cases can be collected to rechallenge of ICIs after the incidence of cardiac toxicity.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular adverse events associated with immune checkpoint inhibitors: a meta-analysis

Li,

2024

Front. Immunol.

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ObjectiveTo evaluate the cardiovascular safety of anticancer drug immune checkpoint inhibitors (ICIs) used in patients with malignant tumors.MethodsFour clinical research databases that have been completed since their establishment were searched, and the odds ratios and 95% confidence intervals of each indicator were statistically calculated.Results62 randomized controlled trial and controlled trials were included. In single drug treatment ICIs group, the overall risk of cardio cerebral Vascular disease at all levels was higher than that in the placebo/chemotherapy group. Especially in all grades of Myocarditis and above grade 3 compared with normal controls, except for pericardial lesions, other indicators have no obvious side effects.ConclusionSingle drug use of an anti-tumor ICIs may increase cardiovascular side effects risk in cancer patients, so we need to strengthen monitoring, identification and management, and timely intervention to manage ICI induced adverse events.

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Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 1—Primary Immunodeficiencies

Napiórkowska-Baran,

Doligalska,

Drozd

et al. 2024

Healthcare

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Background: Cardiovascular diseases are some of the most prevalent chronic diseases that generate not only high social but also economic costs. It is becoming increasingly crucial to take into account inborn errors of immunity (IEIs, formerly known as primary immunodeficiencies (PIDs)) and secondary immunodeficiencies (SIDs) in the diagnostic and therapeutic management of cardiac patients. The number of diseases classified as IEIs is on the rise, with a current total of 485. It is essential to pay attention not only to already confirmed conditions but also to symptoms suggestive of immunodeficiencies. Objectives: The aim of this article is to present IEIs with cardiovascular symptoms that may cause or exacerbate cardiovascular disease, as well as diagnostic and therapeutic procedures. Results: It is becoming increasingly evident that immunodeficiencies can be responsible for certain cardiovascular conditions, their hastened progression, and difficulties in their control. Conclusions: Early detection of deficiencies improves not only the quality and longevity of patients, but also allows for better control of cardiovascular diseases and even prevention of their occurrence.

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Acute pericarditis: A peculiar manifestation of common variable immune deficiency

Cited by 3 publications

References 17 publications

Pyopericardium presenting as pericardial tamponade in a patient with common variable immunodeficiency disorder

Pyopericardium presenting as pericardial tamponade in a patient with common variable immunodeficiency disorder

Cardiovascular adverse events associated with immune checkpoint inhibitors: a meta-analysis

Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 1—Primary Immunodeficiencies

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