Acute Pericarditis Leading to a Diagnosis of SLE: A Case Series of 3 Patients

Narang, Vishal K; Bowen, Jonathan P.; Masarweh, Omar; Burnette, Shane; Valdez, Michael; Moosavi, Leila; Joolhar, Fowrooz; Win, Theingi Tiffany

doi:10.1177/23247096221077832

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…This case further emphasizes the critical importance that the treatment of acute pericarditis always presupposes identifying the underlying cause for a more appropriate approach to this pathology. As demonstrated in this case, pericardiocentesis is a vital diagnostic tool for determining the etiology, as documented in the literature through different clinical case reports [6][7][8][9].…”

Section: Discussionmentioning

confidence: 81%

Purulent Pericarditis in End-Stage Renal Disease: A Rare Case of Citrobacter freundii Infection

Goncalves,

Sá,

Simoes

et al. 2024

Cureus

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Section: Discussionmentioning

confidence: 81%

Purulent Pericarditis in End-Stage Renal Disease: A Rare Case of Citrobacter freundii Infection

Goncalves,

Sá,

Simoes

et al. 2024

Cureus

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“…Pericarditis is the most common cardiac manifestation of SLE [ 24 ]. However, it is uncommon for acute pericarditis to be the leading symptom at the time of diagnosis of SLE, and it occurs in just 1% of patients [ 25 ]. A case report by Bezwada et al discussed myopericarditis with pericardial effusion as the initial presentation of SLE [ 26 ].…”

Section: Reviewmentioning

confidence: 99%

“…At the same time, a CT scan of the chest revealed pericardial effusion, pericardial thickening, and normal lung parenchyma with mild bilateral pleural effusion. Narang et al published a case series discussing three patients who developed acute pericarditis without prior history of SLE but were later diagnosed with SLE [ 25 ]. On investigation, two of these cases had the classical electrocardiography finding of diffuse ST-segment elevation with PR interval depression.…”

Section: Reviewmentioning

confidence: 99%

“…At the same time, one demonstrated low voltage without signs of PR and ST-segment changes and electrical alternans. Non-steroidal anti-inflammatory drugs (NSAIDs) are the primary choice in managing pericarditis; however, SLE treatment includes disease-modifying anti-rheumatologic drugs (DMARDs), glucocorticoids, and even immunomodulators as SLE is an organ-threatening condition [ 25 ].…”

Section: Reviewmentioning

confidence: 99%

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Systemic Lupus Erythematosus and Cardiovascular Diseases: A Systematic Review

Nor¹,

Ogedegbe²,

Barbarawi³

et al. 2023

Cureus

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Systemic lupus erythematosus (SLE) is an autoimmune condition characterized by multi-organ involvement. The clinical presentation often varies from mild to moderate to severe. The cardiovascular system may also be affected, often portending a poor prognosis for patients. Although the relationship between SLE and cardiovascular disorders has been extensively explored through case reports and literature reviews, few systematic reviews explicitly focusing on this association have been conducted. In light of this, this systematic review aims to analyze the extent of the association between SLE and cardiovascular diseases (CVDs), by exploring the risk of developing CVDs, including myocardial infarction (MI), atherosclerosis, myocarditis, pericarditis and arrhythmias, in SLE patients vs. non-SLE patients. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to perform the systematic review. A detailed search was done covering the period from March 2003 to March 2023 using three databases: PubMed, Google Scholar, and Cochrane. The PubMed search identified 597 articles, while Google Scholar and Cochrane searches yielded 559 and three articles, respectively. Of the 1159 articles retrieved, we chose eight for final consideration, after excluding papers that did not discuss the role of SLE in CVDs, papers published earlier than 2003, and papers with incomplete data. The eight studies chosen included two narrative reviews, two systematic reviews, and four observational studies. In this systematic review, SLE was proven to have a strong relationship with diverse CVDs, including rare ones scarcely discussed in the literature, such as vasculitis and aortic dissection. All eight of the final papers indicated a connection between SLE and CVDs, based on the systematic analysis of these articles, which revealed that most recent research supports a higher risk of peripheral arterial occlusive disease (PAOD), MI, pericarditis, myocarditis, and other cardiovascular disorders in individuals with SLE. These associations may have certain gray areas, as patient characteristics and comorbidities often affect the extent of illness and long-term prognosis. Larger-scale studies are required to probe this relationship further and research the etiopathogenesis involved in order to improve patient outcomes. The effects of SLE on the heart are, however, unequivocal.

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“…We initially began treatment with steroids and hydroxychloroquine. The patient’s lower limb edema and hypoalbuminemia showed improvement [ 5 ]. However, there was a recurrence of pericardial fluid accumulation, requiring weekly aspirations for nearly three weeks.…”

Section: Case Presentationmentioning

confidence: 99%

Pericardial Effusion as the Initial Presentation of Systemic Lupus Erythematosus in a 37-Year-Old Female

Shalomi,

Ramesh

2023

Cureus

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can affect various organs and systems in the body, leading to a wide range of clinical manifestations. Pericardial effusion, which is an accumulation of excessive fluid in the pericardial sac surrounding the heart, can be one of the early presentations of SLE in some individuals. When it occurs in young females, it can be particularly concerning, as SLE predominantly affects women of childbearing age. In this case report, we describe pericardial effusion as the initial presentation of SLE in a 37-year-old mother of four children. Importantly, early diagnosis and consistent follow-up are critical for improving the prognosis and quality of life for individuals with SLE.

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Acute Pericarditis Leading to a Diagnosis of SLE: A Case Series of 3 Patients

Cited by 4 publications

References 24 publications

Purulent Pericarditis in End-Stage Renal Disease: A Rare Case of Citrobacter freundii Infection

Purulent Pericarditis in End-Stage Renal Disease: A Rare Case of Citrobacter freundii Infection

Systemic Lupus Erythematosus and Cardiovascular Diseases: A Systematic Review

Pericardial Effusion as the Initial Presentation of Systemic Lupus Erythematosus in a 37-Year-Old Female

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