Acute phase protein levels in pregnancy and oestrus cycle in bitches

Ulutaş, Pınar Alkım; Musal, Bayazit; Kiral, Funda; Bildik, Ayşegül

doi:10.1016/j.rvsc.2008.09.001

Cited by 40 publications

(37 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In veterinary clinical medicine, some of the topics recently investigated about fibrinogen in farm animals (cattle, horses, pigs, dogs, excluding for the latter two the use as models of human disease; source: PubMed database; period: 2004-09) include: changes related to estrous cycle, pregnancy and parturition [16][17][18][19], liver [20] and heart disease [21][22][23], elective and non-elective surgery [24,25], poisoning/envenomation [26][27][28][29][30], parasite infestation [31][32][33], viral infection [34,35]. The issue most often on focus is however, by far, bacterial infection -especially in respiratory diseases [34,[36][37][38][39][40][41] -and such of its short-or long-term sequelae as septic shock with coagulopathy [42][43][44][45], laminitis [46], or osteomyelitis [47].…”

Section: Introductionmentioning

confidence: 99%

Any use in proteomics for low-tech approaches? Detecting fibrinogen chains of different animal species in two-dimensional electrophoresis patterns

Miller

Gianazza

Gemeiner

2010

Journal of Chromatography B

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Any use in proteomics for low-tech approaches? Detecting fibrinogen chains of different animal species in two-dimensional electrophoresis patterns

Miller

Gianazza

Gemeiner

2010

Journal of Chromatography B

View full text Add to dashboard Cite

“…Serum levels of ceruloplasmin have been found to increase during normal pregnancy in some species [14], [15] and it is thought that this increase during gestation protects against oxidative stress associated with pregnancy [18], [19], [21]. In dogs, the increase in serum ceruloplasmin has been coupled to the time of embryonic endometrial implantation and placentation [13], [16]. In contrast, our modified CEP assay showed that in giant pandas active ceruloplasmin in urine increases within one week after conception, indicating that this species produces an inflammatory response well before implantation of the embryo (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of some acute phase proteins typically associated with the immune system and inflammation were found to increase during pregnancy in mammals such as humans and dogs [13], [14], [15], [16]. However, daily and even weekly blood collections from endangered/exotic species are challenging to obtain.…”

Section: Introductionmentioning

confidence: 99%

The Acute Phase Protein Ceruloplasmin as a Non-Invasive Marker of Pseudopregnancy, Pregnancy, and Pregnancy Loss in the Giant Panda

et al. 2011

View full text Add to dashboard Cite

After ovulation, non-pregnant female giant pandas experience pseudopregnancy. During pseudopregnancy, non-pregnant females exhibit physiological and behavioral changes similar to pregnancy. Monitoring hormonal patterns that are usually different in pregnant mammals are not effective at determining pregnancy status in many animals that undergo pseudopregnancy, including the giant panda. Therefore, a physiological test to distinguish between pregnancy and pseudopregnancy in pandas has eluded scientists for decades. We examined other potential markers of pregnancy and found that activity of the acute phase protein ceruloplasmin increases in urine of giant pandas in response to pregnancy. Results indicate that in term pregnancies, levels of active urinary ceruloplasmin were elevated the first week of pregnancy and remain elevated until 20–24 days prior to parturition, while no increase was observed during the luteal phase in known pseudopregnancies. Active ceruloplasmin also increased during ultrasound-confirmed lost pregnancies; however, the pattern was different compared to term pregnancies, particularly during the late luteal phase. In four out of the five additional reproductive cycles included in the current study where females were bred but no birth occurred, active ceruloplasmin in urine increased during the luteal phase. Similar to the known lost pregnancies, the temporal pattern of change in urinary ceruloplasmin during the luteal phase deviated from the term pregnancies suggesting that these cycles may have also been lost pregnancies. Among giant pandas in captivity, it has been presumed that there is a high rate of pregnancy loss and our results are the first to provide evidence supporting this notion.

show abstract

“…Pregnancy modifies plasma proteins profile. Acute phase proteins, which include C-reactive protein, serum amyloid A, fibrinogen, and ceruloplasmine, are significantly increased [29, 30] whereas the increase in plasma volume results in a dilutional hypoalbuminaemia, as the synthesis of this protein is not modified. Changes in the concentration of plasma proteins, particularly albumin, may affect drug protein binding, modifying the free fraction of drugs.…”

Section: Pharmacokinetics In Pregnancymentioning

confidence: 99%

“…Total plasma protein levels remain decreased or unchanged; acute phase proteins, including C-reactive protein and fibrinogen, increase in pregnancy, although it cannot be used as pregnancy diagnosis [29, 30]. Similar changes may occur in the queen.…”

Section: Antibiotic Therapy and Teratogenic Risk During Canine Andmentioning

confidence: 99%

Antibiotic Treatment of Dogs and Cats during Pregnancy

Rebuelto

Loza

2010

Veterinary Medicine International

View full text Add to dashboard Cite

The use of pharmacological agents in pregnant females poses a major clinical challenge due to the marked physiological changes that may modify the pharmacokinetics of drugs and to the potential effects on the fetus. The purpose of this paper is to review briefly our knowledge on the use of antibacterial drugs during pregnancy and to provide information for the judicious selection of an antimicrobial treatment for use in pregnant bitches and queens. The risk to the fetus is a result of the ability of a drug to reach the fetal circulation and to produce toxic effects. The placenta functions as a barrier that protects the fetus due to the presence of transporters and metabolising enzymes; however, during pregnancy, the presence and activity of both enzymes and transporters may change. Antimicrobial agents that have been shown to be safe for use during pregnancy include betalactams, macrolides, and lincosamides. Pharmacotherapy during pregnancy in all species may affect adversely the developing fetus; therefore, it should be avoided when possible.

show abstract

Acute phase protein levels in pregnancy and oestrus cycle in bitches

Cited by 40 publications

References 17 publications

Any use in proteomics for low-tech approaches? Detecting fibrinogen chains of different animal species in two-dimensional electrophoresis patterns

Any use in proteomics for low-tech approaches? Detecting fibrinogen chains of different animal species in two-dimensional electrophoresis patterns

The Acute Phase Protein Ceruloplasmin as a Non-Invasive Marker of Pseudopregnancy, Pregnancy, and Pregnancy Loss in the Giant Panda

Antibiotic Treatment of Dogs and Cats during Pregnancy

Contact Info

Product

Resources

About