Acute phase protein levels in dogs with mast cell tumours and sarcomas

Abstract

The acute phase proteins (APP) form part of a non-specific host response to inflammation. They may be induced by a range of different causes, including infection, inflammation, cancer and trauma. As they form part of the earliest response to such insults, they have potential for early identification of disease. In people, APP levels have been shown to correlate both with the extent of disease and also the prognosis in several forms of neoplasia, including prostate, oesophageal and colorectal cancer. As such, they can be used as prognostic and monitoring tools. To date, similar studies in veterinary patients have been limited, largely retrospective in nature and many are non-specific for tumour type. The purpose of this study was to evaluate a panel of four APPs in dogs with naturally occurring mast cell tumours (MCTs) and sarcomas to identify in the first instance whether increased levels of individual APPs, or identifiable combinations of APPs, was linked with the presence of disease. In the patients with MCTs, C-reactive protein (CRP) and α-1 acid glycoprotein levels increased, with a concurrent drop in serum amyloid A levels. In the sarcoma patients, CRP, α-1 acid glycoprotein and haptoglobin were increased. These findings suggest that specific solid tumour types in dogs may be associated with specific changes in APP profiles

Diagnostic value of neutrophil–lymphocyte and albumin–globulin ratios in canine soft tissue sarcoma

“…), mast cell tumours and sarcomas (Chase et al . ) and mammary tumours (Planellas et al . ) compared to healthy controls.…”

“…2007 ), histiocytic sarcoma (Nikolic Nielsen et al . 2013 ), mast cell tumours and sarcomas (Chase et al . 2012 ) and mammary tumours (Planellas et al .…”

Characteristics of extracellular cyclicAMP‐dependent protein kinase as a biomarker of cancer in dogs

“…Among those cancer biomarkers, thymidine kinase 1 (TK1), C‐reactive protein (CRP), α1‐acid glycoprotein (AGP) and haptoglobin have been most extensively evaluated for their correlation with cancer. Measurement of serum TK1 level has been proven to be a useful diagnostic tool for detection of various types of malignant tumours in dogs as well as prediction of clinical outcomes of anti‐cancer therapy in lymphoma patients . However, additional measurement of CRP, a widely accepted biomarker of inflammation, in serum is necessary to improve the limitation of TK1 activity assessment for detecting solid tumours other than hemangiosarcoma in dogs .…”

Genome-wide analysis of androgen receptor binding sites in prostate cancer cells

“…Furthermore, TNFAIP8 expression is significantly associated with a higher risk of prostate cancer recurrence (27). A previous study demonstrated that APP expression levels correlated with the extent of disease and the prognosis in several forms of cancer (28). In addition, SYNE1 is a promising biomarker in colitis-associated colorectal cancer (29).…”