Acute phase proteins and prognostic inflammatory and nutritional index (PINI) in moderately burned children aged up to 3 years

Kudlácková, M; Andĕl, M; Hájková, H; Nováková, J.

doi:10.1016/0305-4179(90)90206-c

Cited by 21 publications

(6 citation statements)

References 22 publications

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“…13 Postburn blood levels of CRP were shown to be not only proportional with the extent of the burn wound area but also with the depth of the wound. 14,15 Interestingly, in nonburn wounds CRP was shown to activate complement locally on a tissue level in various inflammatory diseases, such as myocardial infarction 16 and atherosclerosis. 17 Complement activation product C3d is involved in the opsonization of pathogens and also of dying/damaged cells also through specific C3d receptors expressed on macrophages.…”

mentioning

confidence: 99%

Acute Inflammation is Persistent Locally in Burn Wounds: A Pivotal Role for Complement and C-Reactive Protein

Goot

Krijnen

Begieneman

et al. 2009

Journal of Burn Care & Research

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Severe burns can cause major complications, such as infection and deforming scar formation. Burn wounds induce an excessive inflammatory response. Serum levels of complement and the acute phase reactant C-reactive protein (CRP) are upregulated in response to burn injury and have been shown to be related to the severity of burn trauma and to the clinical outcome. However, complement and CRP have not been investigated on a tissue level locally at the site of the burn trauma. Protein levels and localization of complement activation product C3d and CRP were determined semi-quantitatively in burn eschar between 2 and 46 days after injury, using immunohistochemistry. CD68 and myeloperoxidase (MPO), markers for macrophages and neutrophilic granulocytes, respectively, were also analyzed on these biopsies. Skin biopsies of very recent surgical wounds (seconds old) served as controls. C3d and CRP are present at high levels in the burn wound. Protein levels of both mediators are significantly elevated up to at least 46 days after injury in comparison with control wounds. In line with this, neutrophils and macrophages infiltrate the burn wound in high numbers up to at least 46 days after injury. The excessive presence of the inflammatory mediators, complement and CRP, and the increased infiltration of neutrophils and macrophages in burn woundsup to 46 days after injury implicate a persistent ongoing acute inflammation locally in the burn wound up to weeks after the initial trauma. (J Burn Care Res 2009;30:274 -280)

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confidence: 99%

Acute Inflammation is Persistent Locally in Burn Wounds: A Pivotal Role for Complement and C-Reactive Protein

Goot

Krijnen

Begieneman

et al. 2009

Journal of Burn Care & Research

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“…The early nonspecific response to systemic tissue injury that is responsible for the reprioritization of protein synthesis in the liver is termed the acute phase response (APR) [19][20][21]. Depending on the magnitude and the severity of the injury, APR is characterized by an exponential increase in positive acute phase proteins and a decrease in negative acute phase proteins.…”

Section: Acute Phase Proteins and Acute Phase Responsementioning

confidence: 99%

Biology-based nutritional support of critically ill and injured patients

Dogjani¹,

Zatriqi

Uranues

et al. 2011

Eur Surg

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“…13 The PINI has been measured in several settings (Table 1) and has been found to be a reliable indicator of both nutritional status and prognosis in trauma, burn, infected and cardiac patients. [13][14][15][16][17] However, it has never been evaluated in cancer. We describe a pilot study evaluating the prognostic inflammatory and nutritional index (PINI) in advanced disease and the potential reference values obtained.…”

Section: Introductionmentioning

confidence: 99%

The Cancer Anorexia–Cachexia Syndrome

Nelson

Walsh

2002

Journal of Pain and Symptom Management

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Other than weight loss, most traditional methods of nutritional assessment are not acceptable in advanced cancer patients because they are inaccurate, too expensive for routine use, or too difficult for a debilitated person to complete. The prognostic inflammatory and nutritional index (PINI) is a formula devised to evaluate nutritional status and prognosis in critically ill patients. It has been suggested that the PINI score can be used to follow most pathological conditions. It has been measured in several settings and has been found to be a reliable indicator of both nutritional status and prognosis in trauma, burn, infected, and cardiac patients. In this pilot study, we evaluated the PINI in 50 consecutive patients referred to a palliative care service. Compared to a value in normal, healthy people of <1, the mean score in this sample was 102 (SD = 142, 95% CI = 62-142). The mean protein values were: alpha-1-acid glycoprotein 1409 mg/l (SD = 556, 95% CI = 1251-1567); C-reactive protein (CRP) 106 mg/l (SD = 89, 95% CI = 81-131); albumin 24 g/l (SD = 7, 95% CI = 23-26); and prealbumin 147 mg/l (SD = 73, 95% CI = 126-168). There was no significant association between the PINI and corticosteroid use, weight loss over time, age, or sex. These data indicate that the PINI is highly abnormal in our population. The CRP may be the most important value.

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Acute phase proteins and prognostic inflammatory and nutritional index (PINI) in moderately burned children aged up to 3 years

Cited by 21 publications

References 22 publications

Acute Inflammation is Persistent Locally in Burn Wounds: A Pivotal Role for Complement and C-Reactive Protein

Acute Inflammation is Persistent Locally in Burn Wounds: A Pivotal Role for Complement and C-Reactive Protein

Biology-based nutritional support of critically ill and injured patients

The Cancer Anorexia–Cachexia Syndrome

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