2015
DOI: 10.1007/s00436-015-4628-3
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Acute phase proteins increase with sarcoptic mange status and severity in Iberian ibex (Capra pyrenaica, Schinz 1838)

Abstract: Sarcoptic mange is a contagious skin disease caused by Sarcoptes scabiei, affecting both domestic and wild mammals, including the Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate almost endemic to the Iberian Peninsula. Acute phase proteins (APPs) could be an indicator of sarcoptic mange disease and severity in Iberian ibex. Serum samples from 131 healthy and sarcoptic mange-affected Iberian ibexes were collected from 2005 to 2012 in Sierra Nevada Natural Space in southern Spain. Serum alpha-1-… Show more

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Cited by 25 publications
(32 citation statements)
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“…Serum SAA is an acute phase protein of inflammation [ 36 ]. In our study, serum SAA concentrations increased significantly in the most severe phase of the disease (Table 3 ), which coincides with the description by Ráez-Bravo [ 37 ]. In addition, higher levels were present in ibex in which more tissues with amyloidosis were detected (Table 4 ).…”
Section: Discussionsupporting
confidence: 92%
“…Serum SAA is an acute phase protein of inflammation [ 36 ]. In our study, serum SAA concentrations increased significantly in the most severe phase of the disease (Table 3 ), which coincides with the description by Ráez-Bravo [ 37 ]. In addition, higher levels were present in ibex in which more tissues with amyloidosis were detected (Table 4 ).…”
Section: Discussionsupporting
confidence: 92%
“…However, results in this study fit the differences in two acute phase proteins (APP), namely alpha-1 acid glycoprotein (AGP) and serum amyloid A (SAA), observed in similarly ranked Iberian ibex. The higher APP level in severely affected ibexes was attributed to skin inflammation or the pathological secondary amyloidosis, leading to organ dysfunction in this category [ 74 ]. The increasing % OD values with increasing sarcoptic mange severity found in this study could be explained by a higher intensity of infestation in severely affected ibexes, which in turn would stimulate more intensely the immune system and elicit a higher antibody production.…”
Section: Discussionmentioning
confidence: 99%
“…Among the wild ungulates, a similar form was reported, with renal medullary amyloidosis, in the gazelle (Rideout et al, 1989). In the ibex, a direct relationship between the increase of acute phase proteins and the progressive severity of the mange by Sarcoptes scabiei was reported (Ráez-Bravo et al, 2015). In our case, the systemic amyloidosis is probably connected to the general pathological condition, maybe especially to the intervention of Corynebacterium pseudotuberculosis which causes, as already described, a chronic debilitating disease with purulent collections that spread by tissue contiguity or lymphatic vessels.…”
Section: Parasitological Examination Of Faecesmentioning
confidence: 90%