Acute Phase Reactant Proteins in Cancer

Cooper, Edward H.; Stone, Joan

doi:10.1016/s0065-230x(08)60893-3

Cited by 106 publications

(38 citation statements)

References 130 publications

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“…This is a finding which is in keeping with published data in other malignant disorders (Baruah & Gogoi, 1975;Cooper & Milford Ward, 1979;Cooper & Stone, 1979;Cooper & O'Quigley, 1982;Raynes & Cooper, 1983). However, we did not find an association between disease extent and baseline CRP concentrations.…”

Section: Discussionsupporting

confidence: 92%

“…The serum concentration of the acute phase reactant Creactive protein (CRP) is raised in inflammatory reactions and tissue destruction (Cooper & Milford Ward, 1979;Fischer & Gill, 1976;Powell, 1979) and also in malignant disorders (Baruah & Gogoi, 1975;Cooper & Milford Ward, 1979;Cooper & Stone, 1979;Cooper & O'Quigley, 1982;Raynes & Cooper, 1983). Furthermore, C-reactive protein concentrations have been used to monitor disease activity in both inflammatory (Amos et al, 1977) and malignant diseases (Harshman et al, 1974;Rosenthal & Sullivan, 1979).…”

mentioning

confidence: 99%

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Acute phase reaction during chemotherapy in small cell lung cancer

1990

Lung Cancer

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Acute phase reaction during chemotherapy in small cell lung cancer

1990

Lung Cancer

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“…Similarly, in breast cancer (Steward et al, 1974), lung cancer (Vincent et al, 1975;Ford et al, 1981) and gynaecological cancer (van Nagell et al, 1977) a raised CEA carries a high probability of extensive disease and a poor prognosis. Acute-phase reactant proteins rise nonspecifically in many forms of cancer (Cooper & Stone, 1979). Raised APRPs before treatment are associated with a poor prognosis, as judged by survival, in category T3 and T4 bladder cancer (O'Quigley et al, 1981) and in carcinoma of the bronchus (Bradwell et al, 1980).…”

Section: Resultsmentioning

confidence: 99%

Plasma protein profiles and prognosis in gastric cancer

Rashid¹,

O’Quigley²,

Axon³

et al. 1982

Br J Cancer

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Summary.-In 104 patients with gastric cancer the serum proteins carcinoembryonic antigen (CEA), C-reactive protein (CRP), oil-acid glycoprotein (AGP) (orosomucoid) and a, -antichymotrypsin (ACT) were measured pre-operatively. The estimated median survival of patients with both raised CEA and ACT was only 5 weeks in contrast to 64 weeks for those with both proteins normal. An intermediary group with one of these proteins raised and the other normal had an estimated median survival of 15 weeks. Similar results were obtained by considering a combination of CEA with either AGP or CRP, For these data the results were not explicable in terms of associations between survival time and patient's age, stage, operative procedure, histological classification or site of primary tumour.

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“…Serum CEA concentration in cancer, reflects the integral of the production of CEA by normal and malignant cells, the tumour cell mass and the metabolism of the CEA. By contrast, elevated serum levels of CRP, ACT or AGP, in a patient with cancer in the absence of infection predominantly reflect the effects of stimulation of the liver to increased APRP synthesis in response to blood borne chemical signals derived from tissue destruction in any site (Cooper & Stone, 1979;Kushner, 1982).…”

Section: Discussionmentioning

confidence: 99%