Acute‐phase reactants in infections and inflammatory diseases

Ebersole, Jeffrey L.; Cappelli, David

doi:10.1034/j.1600-0757.2000.2230103.x

Cited by 264 publications

(287 citation statements)

References 105 publications

(161 reference statements)

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“…Acute-phase proteins (app), defined as those whose plasma concentrations increase (positive app) or decrease (negative app) by at least 25% during an episode of inflammation, are measurable indicators of active inflammation (32). Although there are more than 30 different positive and negative app (3,33), serum albumin concentration long has held significance in the ESKD population. Serum albumin is one of the key indicators of dialysis quality (34).…”

Section: Discussionmentioning

confidence: 99%

“…An intense inflammatory cell infiltrate is recruited into the lesion that secretes proinflammatory mediators, including prostaglandin E 2 , IL-1, IL-6, and TNF-␣. Studies have reported that moderate to severe periodontitis can precipitate an acute-phase response (1)(2)(3) and that effective periodontal therapy may be able to decrease systemic markers of inflammation (4).…”

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confidence: 99%

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Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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The relationship between periodontitis and two measures of systemic inflammation, serum albumin and C-reactive protein (CRP), were examined among patients who were receiving chronic outpatient hemodialysis. Adult patients at two locations, North Carolina and New York City, were evaluated by dentist examiners. Six sites per tooth (up to 32 teeth per patient) were examined. A periodontitis case was defined as >60% of sites with attachment level >4 mm. Multivariable logistic regression was used to determine the association of periodontitis with low serum albumin, defined as <3.5 mg/dl, and with high CRP, defined as >3.0 mg/dl. A total of 154 patients completed the study. The mean age was 54.6 yr (SD 13.3), and average duration of dialysis was 4.0 yr (3 mo to 16 yr). Eighty-six (54.6%) were men, and 89 (58.2%) were black. Common causes of end-stage kidney disease were hypertension (12.3%), diabetes (22.1%), glomerulonephritis (7.1%), and other (58.4%). The average number of teeth was 20.3 (SD 8.4). Thirty-five (23%) patients were periodontitis cases. Severe periodontitis was associated with low serum albumin (odds ratio 8.20; 95% confidence interval 1.61 to 41.82; P ‫؍‬ 0.01) compared with individuals without severe periodontitis disease after adjustment for age, gender, race, diabetes, hypertension, body mass index, smoking, study site, total cholesterol, serum calcium, serum phosphorus, and normalized protein catabolic rate. There was no observed association of severe periodontitis with CRP. Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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“…La periodontitis genera bacteriemias y estimula la producción de factores como TNF-α y la interleuquina-6, que presentan la capacidad de estimular a las células hepáticas a producción de proteína C-reactiva. De esa forma se espera encontrar niveles séricos más elevados de PCR en la vigencia de la enfermedad periodontal (17,26).…”

Section: Discussionunclassified

“…Además, las infecciones orales crónicas, en especial las que alcanzan los tejidos periodontales, vienen siendo indicadas como agentes que pueden contribuir al desencadenamiento de una respuesta inflamatoria sistémica debido a la relación existente entre las enfermedades periodontales y episodios inflamatorios (16)(17)(18)(19). Según Dasanayake (20) e Moutsopoulos (21), durante una infección periodontal, mediadores inflamatorios como la interleuquina-1 (IL-1), el factor de II).…”

Section: Introductionunclassified

Proteína C-reactiva ultrasensible en pacientes con y sin periodontitis crónica severa generalizada

Bezerra¹,

Aquino²,

Lima

et al. 2009

Avances en Periodoncia

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Introducción: La proteína C-reactiva ultrasensible (PCR-US) constituye un mediador inflamatorio utilizado como predictor del riesgo cardiovascular que viene siendo investigado como factor indicativo de la relación entre enfermedades cardiovasculares y periodontales. Este trabajo tuvo como objetivo comparar los niveles séricos de proteína C-reactiva entre pacientes con y sin periodontitis crónica severa generalizada. Material y métodos: Se realizó un estudio seccional, utilizando una muestra de 60 pacientes, siendo 29 participantes con enfermedad periodontal (Grupo I) y 31 sin enfermedad (Grupo II). Como criterios de inclusión fueron seleccionados pacientes con diagnóstico de periodontitis crónica severa generalizada. La investigación constó de dos etapas, clínica y bioquímica. La clínica consistió en el examen periodontal y la bioquímica en la recogida de sangre para determinación de los niveles de PCR-US y un hemograma. Resultados: El grupo con enfermedad periodontal presentó una media de 0,36 mg/dl, mientras el sin enfermedad de 0,17 mg/dl (p=0,061). El riesgo cardiovascular para el grupo I fue clasificado como alto para 27,6% de los participantes y bajo para 72,4%. En el grupo II, 6,45% presentaban alto riesgo y 93,5% bajo riesgo, siendo esa relación estadísticamente significativa obtenida por el test de Fisher (p=0,042), presentando uno OR=5,33; IC95% (1,02-27,4). Las variables interventores investigadas no presentaron asociación estadísticamente significativa con los niveles de PCR-US. Conclusión: EL estudio indicó que pacientes portadores de periodontitis crónica severa generalizada no presentaron niveles séricos de PCR-US estadísticamente diferente de los pacientes sin enfermedad. La periodontitis actuó como factor asociado para la elevación de los niveles de la PCR-US, aunque con frágil asociación.

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“…Trabalhos realizados no Brasil estimam que a DP esteja de alguma forma presente em 45 a 79% da população, diferindo de acordo com os critérios utilizados para sua mensuração (Cortelli et al, 2005;Susin et al, 2004aSusin et al, , 2004b2005a Outras publicações que avaliaram a mesma relação, apesar de suas limitações, estão de acordo com esses achados (Naugle et al, 1998;Klassen;Krasko, 2002;Craig et al, 2008 Embora a DP possua natureza crônica, elementos da fase aguda fazem parte da imunidade inata do hospedeiro. Os periodontopatógenos possuem a capacidade de estimular a produção de mediadores, como a PCR pelo fígado (Ebersole;Cappelli 2000, Loos, 2005. A PCR é uma proteína da fase aguda presente em níveis aumentados na DP (Paraskevas et al, 2008) e um importante fator preditor de morte por DCV na população em geral e nos renais crônicos em HD (Kshirsagar et al, 2009 .…”

Section: Revisão Da Literaturaunclassified

Prevalência da doença periodontal em pacientes com doença renal crônica em hemodiálise

Possamai¹

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Acute‐phase reactants in infections and inflammatory diseases

Cited by 264 publications

References 105 publications

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Proteína C-reactiva ultrasensible en pacientes con y sin periodontitis crónica severa generalizada

Prevalência da doença periodontal em pacientes com doença renal crônica em hemodiálise

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