2006
DOI: 10.1016/j.intimp.2006.03.008
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Acute phase response-associated systemic neutrophil mobilization in mice bearing tumors treated by photodynamic therapy

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Cited by 60 publications
(61 citation statements)
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References 25 publications
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“…For example Cecic et al 33 assessed C3 content in Photofrin-PDT-treated tumours and revealed a marked increase in levels of this protein, peaking 3 h after therapy and remaining highly elevated up to 24 h post PDT. Similar findings were reported by Cecic et al 36 . These authors found that complement activity was elevated immediately after Photofrin-PDT, increased about two-fold at the peak interval of 6 h post PDT, remained elevated during the next 6 h, and declined to pre-treatment levels 24 h post PDT.…”
Section: Complement Activationsupporting
confidence: 92%
“…For example Cecic et al 33 assessed C3 content in Photofrin-PDT-treated tumours and revealed a marked increase in levels of this protein, peaking 3 h after therapy and remaining highly elevated up to 24 h post PDT. Similar findings were reported by Cecic et al 36 . These authors found that complement activity was elevated immediately after Photofrin-PDT, increased about two-fold at the peak interval of 6 h post PDT, remained elevated during the next 6 h, and declined to pre-treatment levels 24 h post PDT.…”
Section: Complement Activationsupporting
confidence: 92%
“…The extent of PDT-induced neutrophilia is markedly less pronounced in adrenalectomized host mice compared to normal hosts [55]. This reveals the engagement of the adrenal-pituitary axis, one of the hallmarks of acute phase response, with the release of adrenocortical hormones that contribute to the neutrophilia expression.…”
Section: Acute Phase Responsementioning
confidence: 89%
“…However, several studies have indicated that local PDT treatment of tumours can result in wide-spread effects including systemic neutrophilia (Cecic et al, 2001), induction of acute-phase proteins (Cecic et al, 2001;Gollnick et al, 2003), increased circulating levels of complement proteins (Cecic et al, 2006) and systemic release of pro-inflammatory cytokines (Nseyo et al, 1990;Ziolkowski et al, 1996;de Vree et al, 1997;Cecic and Korbelik, 2002;Gollnick et al, 2003;Yom et al, 2003), all of which indicate the presence of a systemic inflammatory response. Subsequent studies showed that local PDT treatment of murine tumours results in the induction of anti-tumour immunity and resistance to subsequent tumour challenge (reviewed in Canti et al, 2002;Castano et al, 2006).…”
mentioning
confidence: 99%