“…However, several studies have indicated that local PDT treatment of tumours can result in wide-spread effects including systemic neutrophilia (Cecic et al, 2001), induction of acute-phase proteins (Cecic et al, 2001;Gollnick et al, 2003), increased circulating levels of complement proteins (Cecic et al, 2006) and systemic release of pro-inflammatory cytokines (Nseyo et al, 1990;Ziolkowski et al, 1996;de Vree et al, 1997;Cecic and Korbelik, 2002;Gollnick et al, 2003;Yom et al, 2003), all of which indicate the presence of a systemic inflammatory response. Subsequent studies showed that local PDT treatment of murine tumours results in the induction of anti-tumour immunity and resistance to subsequent tumour challenge (reviewed in Canti et al, 2002;Castano et al, 2006).…”