Acute‐phase response following full‐mouth <i>versus</i> quadrant non‐surgical periodontal treatment: A randomized clinical trial

Graziani, Filippo; Cei, Silvia; Orlandi, Marco; Gennai, Stefano; Gabriele, Mario; Filice, Natalia; Nisi, Marco; D’Aiuto, Francesco

doi:10.1111/jcpe.12451

Cited by 61 publications

(91 citation statements)

References 37 publications

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“…Comparison of FMD and Q-SRP revealed that FMD was moderately better than Q-SRP in reducing probing depth and increasing clinical attachment level (13). Therefore, we used FMD and FM-SRP as the treatment of choice to restrict the cumulative effect of bacteremia and avoid repeated acute inflammation during treatment (16,17). As a result, significant improvements were observed in all periodontal parameters throughout the study period in both groups.…”

Section: Discussionmentioning

confidence: 99%

The clinical and systemic effects of periodontal treatment in diabetic and non-diabetic obese patients

et al. 2016

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Section: Discussionmentioning

confidence: 99%

The clinical and systemic effects of periodontal treatment in diabetic and non-diabetic obese patients

et al. 2016

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“…Although SRP improves systemic inflammation in the long term, intense non‐surgical periodontal therapy including FM‐SRP acts as a potent inflammatory stimulus immediately after treatment, and induces an acute inflammatory response . Recently, Graziani et al reported that FM‐SRP results in a strong systemic acute‐phase response that includes CRP and IL‐6, after 24 hours in patients with periodontitis. It is thus a concern that the marked systemic spread of inflammatory mediators from periodontal pockets and tissues following FM‐SRP might cause transient hypercytokinemia.…”

Section: Introductionmentioning

confidence: 99%

“…Most previous studies in this field have mainly focused on the clinical and microbiological effects of FM‐SRP; knowledge of the contribution of FM‐SRP to the systemic biological response is limited. In addition, little information is available regarding the systemic acute‐phase response including fever and the production of inflammatory mediators after FM‐SRP . Furthermore, as far as we are aware, no study has concurrently evaluated changes in serum and gingival crevicular fluid inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

Increased systemic levels of inflammatory mediators following one‐stage full‐mouth scaling and root planing

Morozumi

Yashima

Gomi

et al. 2018

J of Periodontal Research

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“…Recent data suggested that NSPT performed fully within 24 hours may induce greater disturbance of systemic inflammation when compared with quadrant scaling . To overcome this issue, different modifications to the original FMD protocol have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Clinical and patient‐centered outcomes post non‐surgical periodontal therapy with the use of a non‐injectable anesthetic product: A randomized clinical study

Marconcini

Goulding²,

Oldoini

et al. 2019

J of Invest & Clin Dent

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Aim The aim of this study was to determine the impact of different full‐mouth decontamination (FMD) protocols on the effectiveness of an intrapocket anesthetic gel in periodontal maintenance patients. Methods Patients undergoing the periodontal maintenance program and with the need for FMD participated in this study. Patients were randomly allocated to non‐surgical periodontal therapy (NSPT) with either a preparatory 15‐day decontamination phase, including chlorhexidine mouth rinse and domiciliary hygiene instructions (modified FMD: test group), or without it (FMD: control group). In both groups, NSPT was performed with the aid of a non‐injectable anesthetic gel. Clinical and patient‐related outcomes were recorded during a 6‐month follow‐up period. Results Sixty patients completed the 6‐month study. Both groups experienced relevant clinical improvements after NSPT, but the test group showed a significant change in periodontal parameters already after the initial 15‐day preparatory period, and overall significantly better results in periodontal outcomes when compared with the control group at the last 6‐month follow up: the gingival index was 2.07 ± 1.25 in the control group and 1.13 ± 0.51 in the test group. Less pain and dental‐related anxiety were perceived by patients in the test group showing a 6‐month mean visual analog scale of 2.13 ± 1.25 in the control group and 1.13 ± 0.83 in the test group. Conclusion The present study suggested that the modification of the standard FMD could improve the clinical efficacy of non‐injectable anesthetic, along with patients’ short‐ and mid‐term appreciation and compliance.

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Acute‐phase response following full‐mouth versus quadrant non‐surgical periodontal treatment: A randomized clinical trial

Abstract: FM-SRP triggers a moderate acute-phase response of 24 h duration compared to Q-SRP. Further research is needed to assess the eventual impact of such findings on the risk of vascular events is advocated. (ClinicalTrials.gov NCT01857804).

Cited by 61 publications

References 37 publications

The clinical and systemic effects of periodontal treatment in diabetic and non-diabetic obese patients

The clinical and systemic effects of periodontal treatment in diabetic and non-diabetic obese patients

Increased systemic levels of inflammatory mediators following one‐stage full‐mouth scaling and root planing

Clinical and patient‐centered outcomes post non‐surgical periodontal therapy with the use of a non‐injectable anesthetic product: A randomized clinical study

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