Acute phase response in organic lambs associated with colostrum serum amyloid A, weight gain, and Cryptosporidium and Giardia infections

Niine, Tarmo; Peetsalu, Kristel; Tummeleht, Lea; Kuks, Ants; Orro, Toomas

doi:10.1016/j.rvsc.2018.10.013

Cited by 6 publications

(9 citation statements)

References 32 publications

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“…The present study revealed a relationship between the serum GGT activity and the IgG concentrations in lambs. The mean SGGTA prior to the colostrum intake (0 h), day 1, 2, 4, 7, 14 and 28 in our study were comparable, either lower or higher than those reported for the corresponding days in previous studies (Pauli 1983;Maden et al 2003;Britti et al 2005;Massimini et al 2006;Niine et al 2018). These different figures found in the SGGTA during the neonatal period in healthy lambs could be attributed to the different measuring methods (Maden et al 2003;Massimini et al 2006), the colostral management practices exercised (i.e., the feeding time, amount of colostrum received, quality of colostrum), the sample size, the health status of the lambs (Tessman et al 1997;Maden et al 2003;Massimini et al 2006) in the studies mentioned above.…”

Section: Discussionsupporting

confidence: 56%

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Kirmizigul¹,

Atakisi²,

Kuru³

et al. 2021

Vet. Med.

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The main goal of this study was to find a link between colostrum and the 1-day-old lamb serum γ-glutamyltransferase (GGT) activity and immunoglobulin G (IgG) concentration and their relation with neonatal diseases and beyond. Further, to set a linear relationship between the serum GGT activity (SGGTA) and the IgG concentration (SIgGC) in different days of the neonatal period, thereby determining the feasibility of the GGT activity in the prediction of the colostrum quality and passive immunity and to define a cut-off point for the SGGTA associated with an increased risk of illness or death in lambs. For this purpose, blood samples were obtained from the lambs before the colostrum intake (day 0) and on different days (1, 2, 4, 7, 14 and 28) in the neonatal period. The colostrum was collected from the respective ewes (n = 254) related to the lambs. The most accurate (R<sup>2</sup> = 0.652) model for predicting the SIgGC or passive immune status was the multiple regression model developed to calculate ln[IgG] from ln[GGT] in healthy neonatal lambs using the serum GGT and IgG values of day 0, 1, 2, 4, 7, 14 and 28. The In[GGT] activity at 24 h after birth in lambs that died or became ill during the neonatal period accounted for approximately 77% and 88% of the variation in the ln[IgG] concentration at 24 h after birth, respectively. The study revealed that SGGTA-24 > 500 IU may be considered as a critical cut-off point for the adequate colostral passive transfer. This study also disclosed that the colostral GGT activity might be used as an indicator to determine the colostrum quality.

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Section: Discussionsupporting

confidence: 56%

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Kirmizigul¹,

Atakisi²,

Kuru³

et al. 2021

Vet. Med.

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“…Then, studies with these hosts are also relevant for the economy. (34,35) Despite the high prevalence of Giardia in humans, and the largest diversity of animals in the world, the Brazilian contribution to the understanding of G. duodenalis diversity is scarce. In relation to developed countries, such as Portugal, Spain, Italy and China, Brazil has few studies of G. duodenalis genotyping, and most of them are concentrated in a single region.…”

Section: Frequency and Distribution Of Genotyping Studies In Brazilmentioning

confidence: 99%

Epidemiology of Giardia duodenalis assemblages in Brazil: there is still a long way to go

Fantinatti

Gonçalves-Pinto

Lopes-Oliveira

et al. 2020

Mem. Inst. Oswaldo Cruz

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Giardia duodenalis infection is distributed worldwide and can achieve prevalence around 60%, especially in developing countries. This protozoan is divided into eight assemblages, in which A and B have high zoonotic potential, whereas C to H are host-specific. This scenario is changing as molecular studies progress, highlighting that knowledge on host-specificity still has a long way to go. Understanding the players involved in transmission routes enables rational designs of control strategies. Considering the high prevalence of giardiasis, this review aims to gather together the data on available studies on the distribution of G. duodenalis assemblages in Brazil until September 2020.

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“…In calves, it has been shown that colostrum SAA isoforms do not directly cross calf intestines (Orro et al, 2008). Our previous studies demonstrated that ewe colostrum SAA and lamb serum SAA were positively associated during the first 5 d of life, and we hypothesized that colostrum has a direct influence on the systemic innate immune response of lambs (Niine et al, 2018a;Peetsalu et al, 2019). The present study did not confirm this hypothesis, but because lambs, in contrast to calves, have ad libitum access to colostrum, the colostrum effect may be different in these 2 species.…”

Section: Discussionmentioning

confidence: 90%

“…The concentrations of different APP change during the first few weeks of ruminant life and are termed age-related changes in APP. In lambs and goat kids, SAA concentrations increase during the first week of life, start to decrease during the second week, and then stabilize at the end of the third week (Eckersall et al, 2008;Ulutas et al, 2017;Niine et al, 2018a;Peetsalu et al, 2019;Dinler et al, 2020). It has been suggested that colostrum intake influences the APP concentration in calves, as their SAA concentrations were found to be low before colostrum consumption and then increased during the first 24 h after birth (Orro et al, 2008;Tóthová et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of colostrum on the acute-phase response in neonatal dairy calves

Peetsalu

Niine

Loch

et al. 2022

Journal of Dairy Science

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The core part of the mammal innate immune system is the acute-phase response (APR), during which acutephase proteins (APP) are synthesized. Colostrum contains immunomodulating factors such as proinflammatory cytokines and APP in large quantities. We looked at proinflammatory cytokines [IL-1β, IL-6, and tumor necrosis factor-α (TNF-α)] and APP [serum amyloid A (SAA) and haptoglobin (Hp)] in colostrum and in calves' serum. The aim of this study was to evaluate the effects of colostrum on the calves' systemic APR and the associations of the calves' serum APR with short-and long-term weight gain (at the age of 1, 3, and 9 mo). A total of 143 female dairy calves were studied during their first 3 wk of life. The calves were separated from their mothers immediately after birth and bottle-fed 3 L of quality-controlled colostrum once within 2 h after birth. Serum samples were collected once a week during the first 3 wk of life (a total of 1-3 samples per calf). Mean sampling age (±standard deviation) was 4.3 (±2.0) d in the first week, 11.0 (±2.0) d in the second week, and 18.0 (±2.0) d in the third week. Linear regression models were used to study associations of colostrum APP and cytokine concentration with serum APR markers and for studying associations of colostrum and serum APR markers with calves' average daily weight gain (ADWG). Mixed linear regression models were used to compare serum concentrations of APR markers by study weeks. The colostrum IL-6 concentrations were positively associated with serum IL-6 in the first 3 wk of life. Colostrum IL-1β was positively associated with calves' serum IL-1β during the first week of life, and colostrum TNF-α was positively associated with calves' serum TNF-α during the first 2 wk of life. Serum IL-1β concentrations differed over the 3 wk, being the highest during the first week and the lowest during the second week. For IL-6, the concentration during the first week was the highest, and for TNF-α, a steady decline in the concentration was observed. Serum SAA concentrations were elevated during the first 2 wk of life and subsequently declined during the third week. Albumin concentrations were lowest in the first week, whereas Hp concentrations were highest during the second week. Serum concentrations of SAA, Hp, IL-6, and TNF-α during the second week were negatively associated with ADWG at 9 mo of age. The SAA concentrations during the third week of age had a negative association with 9-mo ADWG. Serum Hp concentrations in the third week were negatively associated with 3-mo ADWG. The results of our study suggest that colostrum cytokines influence calf serum cytokine concentrations. Thus, they influence the newborn calves' adaptation to the environment and the development of their immune system. Factors that activate an APR during the second and third week of life have a long-term influence on calves' development.

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Acute phase response in organic lambs associated with colostrum serum amyloid A, weight gain, and Cryptosporidium and Giardia infections

Cited by 6 publications

References 32 publications

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Epidemiology of Giardia duodenalis assemblages in Brazil: there is still a long way to go

Effect of colostrum on the acute-phase response in neonatal dairy calves

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Acute phase response in organic lambs associated with colostrum serum amyloid A, weight gain, and Cryptosporidium and Giardia infections

Cited by 6 publications

References 32 publications

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Epidemiology of Giardia duodenalis assemblages in Brazil: there is still a long way to go

Effect of colostrum on the acute-phase response in neonatal dairy calves

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Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life

Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life