“…Modern ideas about the nature and mechanisms of AP development, based on an overestimated assessment of the role of the microbial factor in the interpretation of any negative consequences of the disease, narrow the direction of research on this problem and make it difficult to find scientific explanations for the observed contradictions between theory and practice. The only way out of this impasse is through a radical revision of the AP doctrine, since the explanation of such discrepancies depends on the influence of already known and generally accepted biological rules and laws (6). Meanwhile, in the light of the above, when evaluating the results of correction of terminal States, it seems necessary to distinguish a group of patients with AP into a separate one, which will allow analyzing therapeutic actions in the conditions of a unique mechanism of the disease.…”