Acute Pneumonitis after Subcutaneous Injections of Silicone in Transsexual Men

Chastre, Jean; Basset, F; Viau, François; Dournovo, P; Bouchama, Abderrezak; Akesbi, A

doi:10.1056/nejm198303313081307

Cited by 119 publications

(83 citation statements)

References 11 publications

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“…They were non-crystalline, nonbirefringent, non-staining with routine stains, and were presumed to be silicone. Bronchoalveolar lavage (BAL) fluid revealed alveolar hemorrhage with an increase in neutrophils and eosinophils, which was consistent with the observation by Chastre et al (7). Furthermore, alveolar macrophagesexhibited a morphology similar to those observed previously (2, 5-7).…”

Section: Discussionsupporting

confidence: 81%

Acute Pneumonitis Presumed to be Silicone Embolism.

et al. 1994

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A 39-year-old housewife whounderwent intramammaryinjections of a proprietary silicone fluid mixture showed clinical and novel transbronchial lung biopsy (TBLB) findings. She presented with complaints of progressive dyspnea, dry cough, and pleuritic chest pain 2 days after the last silicone injections. The chest X-ray and CTscan showed diffuse interstitial infiltrates. TBLB demonstrated translucent, presumably silicone globules embolized within the pulmonary capillaries. The documentation of intramammary injections, the clinical and radiographic features of acute pneumonitis, and the histopathologic evidence by TBLB, may support the causal relationship between illicit injections and the silicone embolism. Wediscuss the pathogenesis and urge that this potentially toxic source of pulmonary embolism be removed. (Internal Medicine 33: 481-483, 1994)

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Section: Discussionsupporting

confidence: 81%

Acute Pneumonitis Presumed to be Silicone Embolism.

et al. 1994

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“…These patients show mild respiratory symptoms. 6 Our patient reportedly presented 2 weeks after the injection of silicone, though the accuracy of the history was questionable.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Pulmonary Embolism

et al. 2012

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“…There are multiple case reports of acute pneumonitis, silicone embolism, alveolar hemorrhage however there are only few case reports of chronic pneumonitis. Majority of chronic cases are seen in transgender woman with HIV infection as was reported in 2 case reports [4,5] or related to development of autoimmunity [6] as was reported in a woman 30 years following mammoplasty [7] . There is 1 case report of a patient developing pulmonary fibrosis 5 years after silicone injections with relatively stable disease [8] .…”

Section: Discussionmentioning

confidence: 89%

A rare case of delayed chronic pneumonitis following non-medical grade silicone injections in a transgender woman

Sridhara¹,

Baksh²,

Batool³

et al. 2018

JUMD

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We describe a 47-year-old transgender woman with a history of non-medical grade silicone injections given by unauthorized persons 15-20 years prior to presentation who developed interstitial pneumonitis. She suffered acute exacerbations of pneumonitis, developed pulmonary fibrosis with terminal lung disease, acute respiratory distress syndrome and ventilator dependence and died of her illness. In light of the increasing awareness of the health concerns of the transgender population, we review here in the acute and chronic effects of silicone on the lung.

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Acute Pneumonitis after Subcutaneous Injections of Silicone in Transsexual Men

Cited by 119 publications

References 11 publications

Acute Pneumonitis Presumed to be Silicone Embolism.

Acute Pneumonitis Presumed to be Silicone Embolism.

An Unusual Case of Pulmonary Embolism

A rare case of delayed chronic pneumonitis following non-medical grade silicone injections in a transgender woman

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