Acute Porphyromonas gingivalis Subdural Abscess with Brain Abscess in the Left Temporal Lobe: A Case Report and Review of Literature

Huang, Guanlin; Zhou, Xiaoping; Zhang, Zhenyu; Lai, Wentao; Zhong, Qi; Wu, Daxing; Ye, Xinyun

doi:10.2147/idr.s422691

Cited by 2 publications

(1 citation statement)

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“…In the context of the case presented here, the identified pathogens— F. nucleatum , P. gingivalis and P. micra —are anaerobic bacteria, often linked with periodontal diseases, and have been implicated in distant site infections, including brain abscesses [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Yet their direct association with ischemic stroke remains rare and underreported.…”

Section: Discussionmentioning

confidence: 99%

Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction

Kiramira,

Uphaus,

Othman

et al. 2024

Brain Sciences

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Invasive dental procedures, such as wisdom teeth removal, have been identified as potential triggers for vascular events due to the entry of oral bacteria into the bloodstream, leading to acute vascular inflammation and endothelial dysfunction. This study presents the case of a 27-year-old healthy male who developed ischemic stroke resulting from bacteremia after undergoing wisdom teeth extraction. Initially, the patient experienced fever and malaise, which were followed by right-sided hemiplegia. Diagnostic imaging, including a CT scan, identified a subacute infarction in the posterior crus of the left internal capsule, and MRI findings indicated inflammatory changes in the masticatory muscles. Further investigations involving biopsies of the masticatory muscles, along with blood and cerebrospinal fluid samples, confirmed bacterial meningitis with associated vasculitis. Notably, oral bacteria linked to periodontitis, including Porphyromonas gingivalis, Fusobacterium nucleatum, Tannerella forsythia, and Parvimonas micra, were found in the biopsies and microbiological analyses. To the best of our knowledge, this is the first reported case showing that bacteremia following dental procedures can lead to such severe neurological outcomes. This case underscores the importance of recognizing bacteremia-induced vasculitis in patients presenting with neurological symptoms post-dental procedures, emphasizing the broader implications of oral infections in such pathologies.

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