Acute portal venous thrombosis as an extrahepatic manifestation of acute hepatitis A infection

Abstract

Among the many potential causes and risk factors for acute portal venous thrombosis, viral hepatitis has been regarded as a rare associated condition. We present the first case in the literature of a 30-year-old previously healthy male who presented with acute portal venous thrombosis associated with acute hepatitis A virus (HAV) infection, describing the probable pathophysiology mechanism, work-up and treatment pursued. We encourage that hepatitis A serological markers should be routinely included in the investigation for acute portal venous thrombosis of unknown aetiology, in unvaccinated patients with risk factors of a recent HAV exposure.

Portal Venous Thrombosis in Alcoholic Hepatitis: A Relatively Unknown Association

“…Prothrombotic state, either inherited or acquired, might be the cause of PVT in patients without cirrhosis, among which myeloproliferative disease is the most common one. 4 In AH, the increased hepatic vein pressure gradient (HVPG) has a significant role in clinical manifestations. However, the amount and effect of alcohol on HVPG are unclear.…”

A special case of acute portal vein thrombosis

“…Cytomegalovirus (CMV), hepatitis B, and hepatitis C infections can lead to a hypercoagulable state that increases the risk of PVT 2 - 3 . In contrast, hepatitis A virus (HAV) with any form of venous thromboembolism (VTE) have been reported extremely rarely, with only one report in the literature describing cerebral venous thrombosis associated with HAV infection and one case with portal vein thrombosis 4 - 5 . We reported a patient with acute PVT who was diagnosed with acute hepatitis A virus infection in the emergency department.…”