Acute post-streptococcal glomerulonephritis –
immune-mediated acute kidney injury –
case report and literature review

Skrzypczyk, Piotr; Ofiara, Anna; Zacharzewska, Anna; Pańczyk-Tomaszewska, Małgorzata

doi:10.5114/ceji.2021.112244

Cited by 7 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study is in line with the result of a previous study conducted in China [32]. Nephritic syndrome is an immunological complication of infection with group A β-hemolytic streptococcus, the immunological complex where deposited in the membranous of glomeruli it results in damaging the underlying tissue and impaired glomerular filtration, it is characterized by microscopic or gross hematuria, hypertension, edema, oliguria, and AKI occurs as a complication of post-streptococcal glomerular nephritis [39].…”

Section: Discussionsupporting

confidence: 90%

Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa Ethiopia: case-control study

Keneni,

Murugan,

Bizuwork

et al. 2023

BMC Nephrol

View full text Add to dashboard Cite

Background Acute kidney injury (AKI) is a serious health problem in critically ill children. It is associated with poor treatment outcomes and high morbidity and mortality rates. Globally, one in three critically ill children suffers from acute kidney injury. However, limited data are available in Africa, particularly Ethiopia, which highlighting the risk factors related to acute kidney injury. Therefore, this study aimed to identify the risk factors associated with acute kidney injury among critically ill children admitted to the pediatric intensive care unit (PICU) at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods A facility-based unmatched case-control study was carried out on 253 (85 cases and 168 controls) critically ill children admitted to the pediatric intensive care unit from January 2011 to December 2021. Participants were selected using a systematic random sampling technique for the control group and all cases consecutively. Data were collected using a structured checklist. Data were entered using Epi data version 4.6 and analyzed using SPSS version 25. Multivariable analysis was carried out using the adjusted odds ratio (aOR) with a 95% confidence interval (CI) to identify associated factors with acute kidney injury. Statistical significance was set at P < 0.05. Results The median age of the participants was two years. Approximately 55.6% of cases and 53.1% of controls were females. The diagnosis of hypertension (aOR = 5.36; 95% CI: 2.06–13.93), shock (aOR = 3.88, 95% CI: 1.85–8.12), exposure to nephrotoxic drugs (aOR = 4.09; 95% CI: 1. 45- 11.59), sepsis or infection aOR = 3.36; 95% CI: 1.42–7.99), nephritic syndrome (aOR = 2.97; 95% CI:1.19, 7.43), and use of mechanical ventilation aOR = 2.25, 95% CI: 1.12, 4.51) were significantly associated factors with acute kidney injury. Conclusion The diagnosis of sepsis or infection, hypertension, shock, nephrotoxic drugs, demand for mechanical ventilation support, and nephritic syndrome increased the risk of AKI among critically ill children. Multiple risk factors for AKI are associated with illness and severity. All measures that ensure adequate renal perfusion must be taken in critically ill children with identified risk factors to prevent the development of AKI.

show abstract

Section: Discussionsupporting

confidence: 90%

Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa Ethiopia: case-control study

Keneni,

Murugan,

Bizuwork

et al. 2023

BMC Nephrol

View full text Add to dashboard Cite

show abstract

“…Nephritic syndrome is an immunological complication of infection with group A β-hemolytic streptococcus, the immunological complex where deposited in the membranous of glomeruli it results in damaging the underlying tissue and impaired glomerular ltration, it is characterized by microscopic or gross hematuria, hypertension, edema, oliguria, and AKI occurs as a complication of post-streptococcal glomerular nephritis [37].…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa, Ethiopia. Case control study

Keneni

Murugan

Bizuwork

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Acute kidney injury (AKI) is a serious problem in critically ill children. It is associated with poor treatment outcomes and a high rate of morbidity and mortality. Globally, one in three critically ill admitted children suffer from acute kidney injury. However, limited data are available in Africa, particularly in Ethiopia, highlighting the risk factors related to acute kidney injury. Therefore, this study aimed to identify the risk factors associated with acute kidney injury among critically ill children admitted to the pediatric intensive care unit at the Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods: A facility-based unmatched case-control study was carried out on 253 (85 cases and 168 controls) children admitted to the pediatric intensive care unit from January 2011 to December 2021. Participants were selected using a systematic random sampling technique for the control group and all cases consecutively. Data were collected using a structured checklist. Data were entered using Epi data version 4.6 and analyzed using SPSS version 25. Multivariate analysis was carried out using the adjusted odds ratio (AOR) with a 95% confidence interval (CI) to identify associated factors with acute kidney injury. Statistical significance was set at P < 0.05. Results: The median age of the participants was two years. About 55.6 % of cases and 53.1% of controls were females. The diagnosis of hypertension (AOR= 5.36; 95% CI: 2.06- 13.93)], shock (AOR=3.88, 95% CI: 1.85- 8.12), exposure to nephrotoxic drugs (AOR=4.09; 95% CI: 1. 45- 11.59), sepsis or infection AOR=3.36; 95% CI: 1.42-7.99), nephritic syndrome (AOR=2.97; 95% CI :1.19, 7.43), and mechanical ventilation AOR=2.25, 95% CI: 1.12, 4.51) were significantly associated with acute kidney injury. Conclusion: In this study, the diagnosis of sepsis or infection, hypertension, shock, nephrotoxic drugs, demand for mechanical ventilation support, and nephritic syndrome increased the risk of AKI among critically ill children. Multiple risk factors for AKI are associated with illness and its severity. All measures that ensure adequate renal perfusion must be taken in children with identified risk factors to avoid the development of AKI.

show abstract

“…More research is required to understand its effects on genomes, proteome, and at subcellular levels that result in acute and chronic damage to vital organs and sicknesses. forms of infection (Skrzypczyk et al, 2021). Increase in blood urea nitrogen, serum CR, URE, UA, and glucose levels with reduced levels of total protein, albumin, and globulin along with changes in serum electrolyte concentrations, such Na, K, Mg, and Ca, show tissue toxicity and damage to visceral organs.…”

Section: Recommendationmentioning

confidence: 99%

Hematobiochemical, antioxidant, and lipid alterations in mice feed with thermally oxidized coconut oil

Ahmad,

Ilahi,

Khan

et al. 2024

Ital. J. Food Sci.

View full text Add to dashboard Cite

In the present study, the effects of recycled oxidized coconut oil were assessed on hematobiochemical, antioxidant and cardiac markers in albino mice. In all, 24 mice were divided into three groups: group I, II, and III; animals in each group received a normal diet as well as fresh and deep-oxidized coconut oil. The outcomes demonstrated that group III mice fed with thermally oxidized coconut oil revealed a significant alteration in the form of decreased levels of alkaline phosphatase, alanine transaminase, aspartate transaminase, total white blood corpuscle, platelet count, hemoglobin (Hb), Hb concentration, mean corpuscular hemoglobin, and hematocrit (HCT) (p > 0.05). Likewise, levels of triglyceride, cholesterol, and low-density lipoprotein in group III were high, while level of high-density lipoprotein was weakened. Moreover, it was observed that administration of oxidized coconut oil (group III) caused significant changes in the levels of creatinine, uric acid, serum urea, total proteins, globulin, albumin, blood urea nitrogen, and serum glucose as well as concentrations of serum electrolytes, such as calcium, magnesium, potassium, and sodium. This study also showed that group III mice had low levels of glutathione, superoxide dismutase, and radical scavenging capacity and high levels of thiobarbituric reactive substances. However, animals in group II, fed with diet of fresh coconut oil, showed normal levels of all the above-mentioned hematobiochemical, antioxidant, and lipid markers, compared to control mice (group I) and group-III animals. The histological findings of the liver and heart further confirmed the findings of the current investigation, that is, deep-oxidized coconut oil has negative consequences and ought to be avoided.

show abstract

Acute post-streptococcal glomerulonephritis – immune-mediated acute kidney injury – case report and literature review

Cited by 7 publications

References 37 publications

Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa Ethiopia: case-control study

Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa Ethiopia: case-control study

Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa, Ethiopia. Case control study

Hematobiochemical, antioxidant, and lipid alterations in mice feed with thermally oxidized coconut oil

Contact Info

Product

Resources

About