Acute posterior multifocal placoid pigment epitheliopathy with bilateral central retinal vein occlusion

Allee, Steven; Marks, Steven J.

doi:10.1016/s0002-9394(98)00158-5

Cited by 29 publications

(9 citation statements)

References 4 publications

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“…2 Optic nerve edema is common, and venous compression within the optic nerve may lead to retinal vein distension and, rarely, to central retinal vein occlusion. 25 Cystoid macular edema is uncommon.…”

Section: ' Examination Findings and The Role Of Color Photography In mentioning

confidence: 99%

Imaging in the Diagnosis and Management of APMPPE

Steiner¹,

Goldstein²

2012

International Ophthalmology Clinics

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Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an uncommon, self-limited idiopathic condition that was first described by Gass in 1968. 1 APMPPE typically affects young, healthy individuals with a bilateral distribution at onset or, if initially unilateral, involvement of the fellow eye within days to weeks. Over one third of patients report a preceding viral or flu-like illness. 1,2 Visual complaints include photopsias, blurred vision, and paracentral scotomas, with vision being more significantly decreased in cases with foveal involvement. 3,4 Visual prognosis is generally good, with 87% of patients without foveal involvement recovering visual acuity of 20/25 or better. 5 Recurrence of APMPPE has been reported 6 but is uncommon. Cerebral vasculitis is a rare but lifethreatening complication occurring simultaneously or months after onset of ocular disease. 7 A variant, relentless placoid chorioretinitis, has a worse prognosis and shares findings and behavior similar to both APMPPE and serpiginous choroidopathy. 8 The incidence of APMPPE is unclear, but a recently published multicentered 20-year retrospective study showed an annual incidence of 0.15 per 100,000 people in a primarily white demographic. 9 There is no consistently reported sex predilection.Although the etiology of APMPPE is uncertain, it is currently believed to be secondary to a hypersensitivity-induced obstructive vasculitis, resulting in hypoperfusion of terminal choroidal lobules in the posterior pole. These changes result in ischemic injury of the overlying retinal pigment epithelium (RPE) and photoreceptors. Choroidal hypoperfusion within APMPPE lesions, 10 delay of fundus autofluorescence (FAF) changes behind fluorescein angiography (FA) and indocyanine green angiography (ICG) changes, the fact that areas of choroidal hypoperfusion are more

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Section: ' Examination Findings and The Role Of Color Photography In mentioning

confidence: 99%

Imaging in the Diagnosis and Management of APMPPE

Steiner¹,

Goldstein²

2012

International Ophthalmology Clinics

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“…Atypical findings include central retinal vein occlusion, papillitis, periphlebitis, and exudative neurosensory retinal detachment. [13][14][15][16] Optical coherence tomography (OCT) enables noncontact and noninvasive imaging of the retina and can be repeated frequently. Retinal changes in APMPPE demonstrated by the time domain OCT (10-mm resolution) were described so far only in four cases, [17][18][19][20] and another small series on three patients used the ultra-high-resolution OCT (3 mm resolution).…”

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confidence: 99%

Spectral Domain Optical Coherence Tomography Classification of Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Goldenberg

Habot‐Wilner

Loewenstein

et al. 2012

Retina

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“…7 Vascular inflammation is thought to be a component as evidenced by its association with neurosensory hearing loss 8 and central retinal vein occlusions. 9 Patients can present with headache, and some patients develop cerebral vasculitis and ischemia. 10 –13 …”

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confidence: 99%

Subretinal Fluid in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Birnbaum

Blair

Tessler

et al. 2010

Retina

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Purpose The purpose of this study was to describe the clinical finding of macular subretinal fluid by optical coherence tomography in patients with acute posterior multifocal placoid pigment epitheliopathy. Methods Patients with acute posterior multifocal placoid pigment epitheliopathy were identified, and those with macular serous retinal detachment noted clinically and confirmed by optical coherence tomography are described. Results Of 8 patients with acute posterior multifocal placoid pigment epitheliopathy evaluated by the uveitis service at the Illinois Eye and Ear Infirmary between 2003 and 2008, 4 eyes of 3 patients presented with macular subretinal fluid. Confirmatory optical coherence tomography was performed in two patients. Conclusion Acute posterior multifocal placoid pigment epitheliopathy may present clinically with macular subretinal fluid. This finding can be confirmed and monitored with optical coherence tomography.

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Acute posterior multifocal placoid pigment epitheliopathy with bilateral central retinal vein occlusion

Cited by 29 publications

References 4 publications

Imaging in the Diagnosis and Management of APMPPE

Imaging in the Diagnosis and Management of APMPPE

Spectral Domain Optical Coherence Tomography Classification of Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Subretinal Fluid in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

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